{"id":"W3159676041","doi":"10.17504/protocols.io.4vdgw26","title":"CRISPR-Cas9 Genome Editing in Human Primary T Cells v1","year":2019,"lang":"en","type":"preprint","venue":"","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"CRISPR; Genome editing; Cas9; Computational biology; Electroporation; Genome; Biology; Human genome; Gene; Guide RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000688827,0.0006392761,0.0006003058,0.0005030392,0.0007794373,0.0009730426,0.0007234907,0.0009245269,0.01172152],"category_scores_gemma":[0.0005807074,0.0006471833,0.0006976646,0.0007410799,0.00040199,0.0003011149,0.0006036038,0.001719465,0.01582805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000582174,"about_ca_system_score_gemma":0.000991546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002359005,"about_ca_topic_score_gemma":0.002964888,"domain_scores_codex":[0.9990796,0.0001378167,0.00009591089,0.000281212,0.0002500677,0.0001554027],"domain_scores_gemma":[0.9997479,0.00005778795,0.00002002121,0.00008063002,0.00005272181,0.00004096474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003426005,0.00005189713,0.0001918632,0.0002826733,0.00002412672,0.000323777,0.000107763,0.0005858177,0.9672316,0.002938291,0.01336804,0.01455161],"study_design_scores_gemma":[0.00005271968,0.000100731,0.0005644958,0.00002981476,0.00002165069,0.0004924117,0.00002007824,0.001137019,0.9107757,0.0004932996,0.08629449,0.0000175996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1548843,0.005160879,0.6621767,0.001633236,0.002690275,0.003145301,0.06989247,0.01536589,0.08505094],"genre_scores_gemma":[0.4209395,0.006012438,0.3317477,0.001428447,0.0002591991,0.003989626,0.09054644,0.004127971,0.1409488],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01172152,"threshold_uncertainty_score":0.03921241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008355908595171838,"score_gpt":0.2848318457803278,"score_spread":0.276475937185156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}