{"id":"W3159702719","doi":"10.1186/s13046-021-01925-7","title":"Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing","year":2021,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Institut National Du Cancer; Biotechnology and Biological Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Extracellular matrix; Cell biology; Mechanotransduction; Focal adhesion; Stem cell; Mesenchymal stem cell; Epithelial–mesenchymal transition; Integrin; Tenascin C; Biology; Cell migration; Chemistry; Cancer research; Cell; Downregulation and upregulation; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001333919,0.0001857383,0.0003793739,0.0001123857,0.0002473197,0.0001151706,0.0004426443,0.0002721434,0.0009961817],"category_scores_gemma":[0.0002603057,0.0001669475,0.0002700799,0.0003359576,0.0002591529,0.00001982428,0.0007870048,0.0007272007,0.00005584203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751353,"about_ca_system_score_gemma":0.001127973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006863201,"about_ca_topic_score_gemma":0.00008989561,"domain_scores_codex":[0.9959551,0.0007642935,0.0008226776,0.0005154839,0.00139257,0.0005498838],"domain_scores_gemma":[0.9971082,0.0001913188,0.0002570786,0.0003915699,0.001563842,0.0004879792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001571756,0.0004601599,0.0005356469,0.00001801026,0.0001666098,0.0003170452,0.0001219439,0.0000433795,0.9708427,0.000007414035,0.02262938,0.00328591],"study_design_scores_gemma":[0.002191124,0.001089453,0.0001931129,0.0000691802,0.00001104026,0.00008785722,0.0007901187,0.00005427725,0.9807297,0.000008837466,0.014603,0.000172318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884715,0.009613221,0.00006439546,0.0007874938,0.0004642948,0.0002477938,0.00005114157,0.000003594634,0.0002965551],"genre_scores_gemma":[0.9942306,0.001584242,0.0003453611,0.0002969545,0.0006210324,0.00001620981,0.00001754068,0.00003960814,0.0028485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009886931,"threshold_uncertainty_score":0.999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011732239568402,"score_gpt":0.4546613831235518,"score_spread":0.3534881591667115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}