{"id":"W3159702719","doi":"10.1186/s13046-021-01925-7","title":"Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing","year":2021,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Institut National Du Cancer; Biotechnology and Biological Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Extracellular matrix; Cell biology; Mechanotransduction; Focal adhesion; Stem cell; Mesenchymal stem cell; Epithelial–mesenchymal transition; Integrin; Tenascin C; Biology; Cell migration; Chemistry; Cancer research; Cell; Downregulation and upregulation; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005152892,0.0002246037,0.00008380218,0.0001002495,0.00009435413,0.000153979,0.0001116981,0.0001408585,0.0007738069],"category_scores_gemma":[0.00005411982,0.00007348636,0.0001466742,0.00007445846,0.0001370592,0.0001010776,0.0001291723,0.00020214,0.0001527603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002755441,"about_ca_system_score_gemma":0.0001348716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009541879,"about_ca_topic_score_gemma":0.001683182,"domain_scores_codex":[0.9999415,0.000004930654,0.000004926997,0.00001045119,0.00002383241,0.00001445033],"domain_scores_gemma":[0.9999434,0.000004756411,0.00002483893,0.000004234731,0.0000075898,0.00001517243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000260113,0.000005814188,0.0003062042,0.00001878967,0.000001849669,0.00002404101,0.000007675071,0.00006250209,0.9991008,0.00003737128,0.00001866885,0.0003903388],"study_design_scores_gemma":[0.000003825166,0.00006751909,0.008283034,0.000004539933,0.000007202187,0.0001000877,0.00002776907,0.001152655,0.9894274,0.00003176654,0.0008902696,0.00000402664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977443,0.0002720395,0.001050634,0.00003789968,0.000006701799,0.000007706415,0.0001658627,0.00003015541,0.0006847429],"genre_scores_gemma":[0.9983789,0.0001359953,0.0006609411,0.00001638764,0.000001346608,0.000009691019,0.0001678325,0.000004350196,0.0006246214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009541879,"threshold_uncertainty_score":0.002588689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011732239568402,"score_gpt":0.4546613831235518,"score_spread":0.3534881591667115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}