{"id":"W3159733223","doi":"10.3390/cancers13092088","title":"Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Research UK; University of Cambridge; National Health and Medical Research Council; Canadian Institutes of Health Research; Ovarian Cancer Research Fund; U.S. Department of Health and Human Services; National Institutes of Health; Ministerio de Economía y Competitividad; Wellcome Trust; Roswell Park Cancer Institute","keywords":"Endometrial cancer; Biology; ABO blood group system; Genome-wide association study; Odds ratio; Immunology; Internal medicine; Cancer; Endocrinology; Genetics; Single-nucleotide polymorphism; Medicine; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774533,0.0001330419,0.0001781771,0.00004872272,0.0002137651,0.00006165523,0.0001022535,0.000199405,0.00009849446],"category_scores_gemma":[0.0009264664,0.000154455,0.00007566032,0.0003427946,0.00009176055,0.000004772279,0.0001039618,0.0002229793,0.000001819282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963068,"about_ca_system_score_gemma":0.00179174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004114538,"about_ca_topic_score_gemma":0.0003784846,"domain_scores_codex":[0.9985503,0.0001695045,0.0002456309,0.0004399734,0.000261705,0.0003328666],"domain_scores_gemma":[0.9991394,0.00003643909,0.0001178442,0.0002494442,0.0002847093,0.0001721754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002744221,0.000008685165,0.003972416,0.0000114817,0.0003519141,0.000007662561,0.00006067573,0.002696725,0.9847602,0.0001230308,0.0005340418,0.007445703],"study_design_scores_gemma":[0.002623127,0.0001987829,0.01242863,0.00005484085,0.0001832049,0.000006086765,0.0000784372,0.001573079,0.9703934,0.0001968428,0.01187464,0.0003888989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604245,0.003580952,0.0323871,0.0002859672,0.0002418316,0.0006579549,0.001615313,0.00003116507,0.000775251],"genre_scores_gemma":[0.9959688,0.000945179,0.00133539,0.0001004287,0.0006526327,0.0001465423,0.0005303976,0.00003144532,0.0002891835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03554434,"threshold_uncertainty_score":0.6298494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798947630335241,"score_gpt":0.295059840744631,"score_spread":0.2770703644412786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}