{"id":"W3159773726","doi":"10.21203/rs.3.rs-439729/v1","title":"GSTM1 and GSTT1 Double Null Genotypes Determining Cell Fate and Proliferation as Potential Risk Factors of Relapse in Children With Hematological Malignancies After Stem Cell Transplantation. On Behalf of the Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Oak Foundation; National Science Foundation","keywords":"Transplantation; Disease; Genotype; Stem cell; Medicine; Oncology; Null (SQL); Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003432732,0.0001530421,0.0001869536,0.00003983137,0.0001094829,0.00003159701,0.0001043384,0.0001275213,0.000001231965],"category_scores_gemma":[0.00000617705,0.00009458005,0.0001220434,0.00007683389,0.0001449738,0.000006560786,0.00006842156,0.0002414079,1.771519e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003928253,"about_ca_system_score_gemma":0.000103153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005014833,"about_ca_topic_score_gemma":0.0000490724,"domain_scores_codex":[0.9986533,0.0003436772,0.0002624665,0.0003336382,0.0002440772,0.0001628323],"domain_scores_gemma":[0.9994899,0.00005183871,0.0001374691,0.000177507,0.00009089786,0.00005239206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009674225,0.0001376174,0.9542978,0.002060815,0.00005063472,0.000005407373,0.002539527,0.0007657793,0.03905098,0.000006035113,7.58107e-7,0.0001171678],"study_design_scores_gemma":[0.001621165,0.0003727099,0.717926,0.0003445694,0.000367541,0.00001181945,0.0004047265,0.00005949786,0.2787408,0.00001851257,3.888059e-7,0.0001322819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959163,0.002547901,0.0001588465,0.00002186343,0.00001681708,0.0009163259,0.0004119369,0.000002124805,0.000007849176],"genre_scores_gemma":[0.995102,0.004544206,0.0001117065,0.000003871021,0.00002439094,0.00005134768,0.0001343293,0.00001763787,0.00001044429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2396898,"threshold_uncertainty_score":0.3856862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143624796903433,"score_gpt":0.2455952569336477,"score_spread":0.2312327772433044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}