{"id":"W3159775539","doi":"10.1210/jendso/bvab048.1108","title":"MIF Inhibition Suppresses Cell Viability and Induces Apoptosis via the ATF4-CHOP Pathway in Mouse Pituitary AtT-20 Cells","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Macrophage migration inhibitory factor; Apoptosis; Downregulation and upregulation; Cancer research; Viability assay; PI3K/AKT/mTOR pathway; Biology; Internal medicine; Chemistry; Endocrinology; Cytokine; Medicine; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000370108,0.000174261,0.0002801607,0.00002621416,0.0002521157,0.00003654887,0.0002231712,0.0001172795,0.0003458486],"category_scores_gemma":[0.0001091151,0.0001038804,0.0003448614,0.0001707894,0.0002524425,0.0001972427,0.0002180981,0.000814198,0.00001203734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000084143,"about_ca_system_score_gemma":0.000124875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000412812,"about_ca_topic_score_gemma":0.00004700453,"domain_scores_codex":[0.9983421,0.0005867492,0.0005273935,0.0001928008,0.0000997733,0.000251191],"domain_scores_gemma":[0.9987494,0.0003722528,0.0003549615,0.0003035457,0.0001911148,0.0000287462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003166544,0.0001942646,0.002393077,0.00004512135,0.0000692918,0.000007074381,0.001897147,0.00003360098,0.9769854,0.000006539274,0.0181829,0.0001539535],"study_design_scores_gemma":[0.001034181,0.00005803376,0.001639172,0.00002682713,0.00003214318,0.0001799848,0.001756276,0.000003544234,0.9813829,0.000144398,0.01363663,0.0001059063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939054,0.001925116,0.00004650748,0.002844181,0.0009661953,0.0001652983,0.00006177778,0.00001067046,0.00007482791],"genre_scores_gemma":[0.9971561,0.0002212165,0.0001505092,0.0004136238,0.0001291148,0.000005959362,0.000007764444,0.00001326669,0.001902386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004546272,"threshold_uncertainty_score":0.4236119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008594367304322045,"score_gpt":0.215311420435093,"score_spread":0.2067170531307709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}