{"id":"W3159775539","doi":"10.1210/jendso/bvab048.1108","title":"MIF Inhibition Suppresses Cell Viability and Induces Apoptosis via the ATF4-CHOP Pathway in Mouse Pituitary AtT-20 Cells","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Macrophage migration inhibitory factor; Apoptosis; Downregulation and upregulation; Cancer research; Viability assay; PI3K/AKT/mTOR pathway; Biology; Internal medicine; Chemistry; Endocrinology; Cytokine; Medicine; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003233647,0.0005721737,0.0005156172,0.0006227407,0.0003731457,0.0002881105,0.0003030454,0.000577699,0.002318253],"category_scores_gemma":[0.0001063323,0.0002330867,0.0006798507,0.0003778288,0.0003304355,0.0002725846,0.000236545,0.001367985,0.0007103474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003327159,"about_ca_system_score_gemma":0.0002294516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047002,"about_ca_topic_score_gemma":0.001427185,"domain_scores_codex":[0.9995585,0.00006015356,0.00007435351,0.00009468981,0.0001031024,0.0001092167],"domain_scores_gemma":[0.9998605,0.00002920786,0.00003072938,0.00002047221,0.00002238199,0.00003659994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004492189,0.000144311,0.0002189028,0.000132198,0.0000113295,0.0001221461,0.00005811825,0.00008056049,0.9968636,0.0001504755,0.0002860263,0.001483193],"study_design_scores_gemma":[0.0001047757,0.001041138,0.004454148,0.00001830588,0.00003872275,0.0004021164,0.00009568702,0.001830514,0.986839,0.00009585709,0.00506661,0.00001322437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727722,0.008179802,0.008045036,0.0007226433,0.000393099,0.0001230267,0.003695312,0.0005072763,0.005561485],"genre_scores_gemma":[0.9808509,0.00288376,0.006806334,0.0003222305,0.00006081889,0.0003283016,0.002997241,0.00004580638,0.005704662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318253,"threshold_uncertainty_score":0.007755339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008594367304322045,"score_gpt":0.215311420435093,"score_spread":0.2067170531307709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}