{"id":"W3159796955","doi":"10.1101/2021.04.28.441866","title":"Sensory processing dysregulations as reliable translational biomarkers in <i>SYNGAP1</i> haploinsufficiency","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Haploinsufficiency; Neuroscience; Psychology; Biology; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003345668,0.0005908179,0.0003127649,0.000825311,0.0002111382,0.0003583886,0.0001870845,0.0004574053,0.0025054],"category_scores_gemma":[0.0003770494,0.0001179781,0.0001726223,0.0002811835,0.0005475865,0.0001671727,0.000389003,0.0004600204,0.0002684846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056891,"about_ca_system_score_gemma":0.00007888751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433305,"about_ca_topic_score_gemma":0.0002845559,"domain_scores_codex":[0.9998597,0.00002250133,0.00002070324,0.00004220545,0.00003551985,0.00001933046],"domain_scores_gemma":[0.9996554,0.00007498662,0.0001588995,0.00002700371,0.00003076652,0.00005308961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001002692,0.00005484265,0.02423442,0.0001408803,0.00006914887,0.002913594,0.0001361413,0.0001338865,0.9635327,0.0002233503,0.0003450809,0.007213174],"study_design_scores_gemma":[0.00005028268,0.001129433,0.6489804,0.00008046975,0.0001919009,0.01561774,0.0004493094,0.001643042,0.3266605,0.001156913,0.004004808,0.00003519213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946669,0.001093332,0.002095167,0.0001281125,0.00004224758,0.00002326694,0.0007200176,0.0001372397,0.001093675],"genre_scores_gemma":[0.9971865,0.000400107,0.001186161,0.00009341238,0.00001479886,0.00002871212,0.0006712367,0.00003226393,0.0003867708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025054,"threshold_uncertainty_score":0.008381367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03829957447144421,"score_gpt":0.2918091532601573,"score_spread":0.2535095787887131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}