{"id":"W3159801410","doi":"10.1016/j.esmoop.2021.100113","title":"Patient-reported outcomes from STARTRK-2: a global phase II basket study of entrectinib for ROS1 fusion-positive non-small-cell lung cancer and NTRK fusion-positive solid tumours","year":2021,"lang":"en","type":"article","venue":"ESMO Open","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Janssen Pharmaceuticals; National Cancer Institute; Bayer Yakuhin; Ignyta; Loxo Oncology; Eli Lilly Japan; Chugai Pharmaceutical; AstraZeneca; Genentech; Pfizer Japan; Bavarian Nordic; Ipsen; Exelixis; European Medicines Agency; PharmaMar; Celgene; Yakult Honsha; Bayer; Astellas Pharma; Eisai; Daiichi-Sankyo; AstraZeneca España; Ludwig Center at Harvard; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Roche España; Nippon Kayaku; BeiGene; Les Laboratories Pierre Fabre; Helsinn; Boehringer Ingelheim Japan; Taiho Pharmaceutical; Lung Cancer Research Foundation; F. Hoffmann-La Roche; Amgen; Ariad Pharmaceuticals; Ono Pharmaceutical; Takeda Pharmaceutical Company; Novartis Pharma; AbbVie; G1 Therapeutics; Roche; Merck Sharp and Dohme; Novartis; Kissei; Merck; Kyowa Hakko Kirin; Sanofi; Foundation Medicine; GlaxoSmithKline; Servier; Incyte; Pfizer; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Asian Studies Association; Boehringer Ingelheim España; Eli Lilly and Company; Society for Academic Continuing Medical Education","keywords":"Medicine; Quality of life (healthcare); Clinical trial; Oncology; Internal medicine; Cancer; Lung cancer; Phases of clinical research; ROS1; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009848941,0.0002938656,0.0007196508,0.00005112357,0.0003664659,0.00007136085,0.0001130374,0.0000769947,0.0004646174],"category_scores_gemma":[0.00008061124,0.0002405699,0.0001197625,0.0002409154,0.00004058401,0.0001563568,0.000391216,0.0001119039,0.000001616864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028495,"about_ca_system_score_gemma":0.0007731366,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02037309,"about_ca_topic_score_gemma":0.005130378,"domain_scores_codex":[0.9981608,0.0000756959,0.0005284661,0.0006353991,0.0002901413,0.0003094998],"domain_scores_gemma":[0.9983426,0.0002018714,0.0003456639,0.0003632604,0.0005181068,0.0002285044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003327249,0.01584714,0.9100898,0.00008709983,0.004514187,0.0009025818,0.04202963,0.00003700926,0.002631113,0.00002055838,0.004217078,0.01629654],"study_design_scores_gemma":[0.05775047,0.005558145,0.8770282,0.0006808668,0.005996913,0.00003128014,0.02592685,0.0004452745,0.02558393,0.00007227799,0.0004252392,0.0005005869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888981,0.0003414327,0.0001034992,0.0009651577,0.0004312489,0.004870715,0.002572681,0.00002242352,0.001794717],"genre_scores_gemma":[0.9957911,0.00005440933,0.001064411,0.0005280038,0.00006488819,0.0006263924,0.0008843417,0.00003197426,0.0009544213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05442322,"threshold_uncertainty_score":0.9861503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802147598297016,"score_gpt":0.3685137426483788,"score_spread":0.3504922666654087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}