{"id":"W3159801410","doi":"10.1016/j.esmoop.2021.100113","title":"Patient-reported outcomes from STARTRK-2: a global phase II basket study of entrectinib for ROS1 fusion-positive non-small-cell lung cancer and NTRK fusion-positive solid tumours","year":2021,"lang":"en","type":"article","venue":"ESMO Open","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Janssen Pharmaceuticals; National Cancer Institute; Bayer Yakuhin; Ignyta; Loxo Oncology; Eli Lilly Japan; Chugai Pharmaceutical; AstraZeneca; Genentech; Pfizer Japan; Bavarian Nordic; Ipsen; Exelixis; European Medicines Agency; PharmaMar; Celgene; Yakult Honsha; Bayer; Astellas Pharma; Eisai; Daiichi-Sankyo; AstraZeneca España; Ludwig Center at Harvard; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Roche España; Nippon Kayaku; BeiGene; Les Laboratories Pierre Fabre; Helsinn; Boehringer Ingelheim Japan; Taiho Pharmaceutical; Lung Cancer Research Foundation; F. Hoffmann-La Roche; Amgen; Ariad Pharmaceuticals; Ono Pharmaceutical; Takeda Pharmaceutical Company; Novartis Pharma; AbbVie; G1 Therapeutics; Roche; Merck Sharp and Dohme; Novartis; Kissei; Merck; Kyowa Hakko Kirin; Sanofi; Foundation Medicine; GlaxoSmithKline; Servier; Incyte; Pfizer; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Asian Studies Association; Boehringer Ingelheim España; Eli Lilly and Company; Society for Academic Continuing Medical Education","keywords":"Medicine; Quality of life (healthcare); Clinical trial; Oncology; Internal medicine; Cancer; Lung cancer; Phases of clinical research; ROS1; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003364724,0.00174454,0.002231825,0.0004181899,0.0004198035,0.001098793,0.000790306,0.001211241,0.002539484],"category_scores_gemma":[0.001054769,0.0004964967,0.001933427,0.0005909852,0.000778073,0.001157066,0.0008218059,0.002003212,0.0005835406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001006795,"about_ca_system_score_gemma":0.001253992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007496518,"about_ca_topic_score_gemma":0.002084661,"domain_scores_codex":[0.9992585,0.0003077691,0.0000625253,0.0001381054,0.0001031072,0.0001299158],"domain_scores_gemma":[0.9988586,0.0001152597,0.0003614592,0.0000812111,0.0001022425,0.0004811197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.822556,0.033396,0.05546904,0.001696521,0.005602917,0.0002862214,0.0002810403,0.00337425,0.02025475,0.0002742216,0.005916859,0.05089216],"study_design_scores_gemma":[0.474959,0.3496493,0.1591425,0.0001068323,0.004253409,0.0006983478,0.0002025744,0.002013151,0.004227493,0.000338983,0.004270863,0.0001374696],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918979,0.001237798,0.0002625177,0.0001798474,0.00003811363,0.001555779,0.003835927,0.00003166153,0.000960479],"genre_scores_gemma":[0.9804812,0.001192898,0.001043044,0.000558368,0.0001061053,0.00267129,0.01271549,0.00002678886,0.001204707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003364724,"threshold_uncertainty_score":0.01779461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802147598297016,"score_gpt":0.3685137426483788,"score_spread":0.3504922666654087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}