{"id":"W3159804362","doi":"10.1101/2021.04.29.21255920","title":"Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; National Institute for Health and Care Research; World Cancer Research Fund; Wereld Kanker Onderzoek Fonds; Cancer Research UK; Centre International de Recherche sur le Cancer; World Health Organization","keywords":"Incidence (geometry); Germline mutation; APOBEC; Esophageal squamous cell carcinoma; Germline; Biology; Genetics; Mutation; Esophageal cancer; Cancer; Cancer research; Oncology; Internal medicine; Genome; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005577594,0.0001783259,0.0003212126,0.001275856,0.0002445322,0.0007328336,0.0001496688,0.0002776027,0.000985581],"category_scores_gemma":[0.001257021,0.0001668536,0.0003848714,0.001800444,0.0002265767,0.0001486283,0.0005649479,0.000202651,0.000191826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001932651,"about_ca_system_score_gemma":0.0001499307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003248782,"about_ca_topic_score_gemma":0.002954849,"domain_scores_codex":[0.9995332,0.000156056,0.00004227932,0.0001358734,0.00006701401,0.00006562165],"domain_scores_gemma":[0.9993754,0.0001470889,0.0002442372,0.00008226078,0.0001020983,0.00004891144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000285381,0.00001644225,0.985689,0.00007233274,0.000279803,0.0002595711,0.0003386502,0.0004482321,0.006184337,0.0000678875,0.0002208825,0.006137401],"study_design_scores_gemma":[0.000007287114,0.00006892932,0.9966479,0.00001516762,0.00008589985,0.0005829684,0.0005416548,0.0002542654,0.0008639629,0.00003477599,0.0008913268,0.000005869489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976526,0.0003042426,0.0001897756,0.00001760723,0.000002902823,0.00000659124,0.001503643,0.000005832814,0.0003167852],"genre_scores_gemma":[0.9975576,0.0001403911,0.0003379982,0.00001907539,0.000001936573,0.000006348082,0.00181341,0.000004824808,0.0001183097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248782,"threshold_uncertainty_score":0.006459713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873483880719628,"score_gpt":0.2932146645878693,"score_spread":0.274479825780673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}