{"id":"W3159804362","doi":"10.1101/2021.04.29.21255920","title":"Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; National Institute for Health and Care Research; World Cancer Research Fund; Wereld Kanker Onderzoek Fonds; Cancer Research UK; Centre International de Recherche sur le Cancer; World Health Organization","keywords":"Incidence (geometry); Germline mutation; APOBEC; Esophageal squamous cell carcinoma; Germline; Biology; Genetics; Mutation; Esophageal cancer; Cancer; Cancer research; Oncology; Internal medicine; Genome; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002442107,0.000308759,0.0006897931,0.0002569265,0.00004581807,0.00003977035,0.000247324,0.0002855887,0.001137084],"category_scores_gemma":[0.0001925098,0.0002772999,0.0001815919,0.0002033027,0.0001423095,0.00007112556,0.0003574937,0.0009395628,0.00001308723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003394289,"about_ca_system_score_gemma":0.00148988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003305239,"about_ca_topic_score_gemma":0.0003650428,"domain_scores_codex":[0.9973671,0.0001535736,0.0005053804,0.0006380835,0.0009829639,0.0003529263],"domain_scores_gemma":[0.998324,0.0004770855,0.0002032111,0.0005132907,0.0002870681,0.0001953487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004807509,0.0004020157,0.9822038,0.00120281,0.00007927238,0.01175305,0.001619722,0.001007113,0.0009259525,0.0000505852,0.0001080588,0.000166846],"study_design_scores_gemma":[0.002244487,0.0002147731,0.902389,0.0003743717,0.0001243368,0.00001280644,0.00009877916,0.0006124304,0.09323618,0.0004917766,0.00001495124,0.0001861491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9338527,0.06417059,0.00005279843,0.0002690592,0.0002304017,0.0005472585,0.0002591769,0.00002111051,0.0005968444],"genre_scores_gemma":[0.9973046,0.0002016411,0.001119581,0.0001502897,0.0002125654,0.0001259093,0.0006257534,0.00003538161,0.0002243382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09231023,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873483880719628,"score_gpt":0.2932146645878693,"score_spread":0.274479825780673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}