{"id":"W3159811306","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2356","title":"Design of SOOTHE, a Phase 2b Dose Finding Study with BLU-5937, a Selective P2X3 Antagonist, in Refractory Chronic Cough","year":2021,"lang":"en","type":"article","venue":"","topic":"Respiratory and Cough-Related Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bellus Health (Canada)","funders":"","keywords":"Refractory (planetary science); Antagonist; Phase (matter); Medicine; Computer science; Physics; Internal medicine; Astrobiology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002840373,0.002111087,0.003153292,0.0006885635,0.0008100059,0.001417274,0.001278088,0.002555392,0.007314946],"category_scores_gemma":[0.001777041,0.001104119,0.001594463,0.0004004704,0.00108836,0.001079566,0.0003961356,0.003122795,0.001636756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009283724,"about_ca_system_score_gemma":0.00318796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188061,"about_ca_topic_score_gemma":0.003777311,"domain_scores_codex":[0.9990374,0.0004566187,0.00004625481,0.000158208,0.0000688189,0.000232784],"domain_scores_gemma":[0.9992867,0.0001722341,0.000106624,0.00006632211,0.00005951497,0.0003086023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8204907,0.05152331,0.002328405,0.00141564,0.001307328,0.0003387446,0.0003496984,0.002894275,0.06256318,0.001225122,0.004019271,0.05154436],"study_design_scores_gemma":[0.6082713,0.3784475,0.002650348,0.00005698832,0.0006447362,0.0001220634,0.00007265723,0.001016237,0.003020159,0.0005170083,0.005131792,0.0000491993],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9418498,0.002791054,0.004113454,0.001381088,0.0007731667,0.04046058,0.002528844,0.0002890667,0.00581295],"genre_scores_gemma":[0.9085173,0.003147498,0.01113024,0.003947504,0.0006831013,0.05946865,0.00197645,0.0001715482,0.0109577],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007314946,"threshold_uncertainty_score":0.02447093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05876944702710776,"score_gpt":0.3749748327530549,"score_spread":0.3162053857259471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}