{"id":"W3159816509","doi":"10.1101/2020.10.09.333666","title":"Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Social Sciences and Humanities Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba; Children's Hospital Foundation; Research Manitoba; Heart and Stroke Foundation of Canada","keywords":"Hypoxia (environmental); Phosphorylation; Cell biology; Misoprostol; Homeostasis; Mitochondrial permeability transition pore; Biology; Pharmacology; Programmed cell death; Internal medicine; Endocrinology; Chemistry; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008047975,0.0002413444,0.0001981827,0.0001096589,0.0001335538,0.0001407645,0.0002012924,0.000233694,0.00240187],"category_scores_gemma":[0.0000739937,0.00008403698,0.0001815624,0.00007626121,0.0002869542,0.0001289762,0.0001318545,0.0007094797,0.0004361843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957131,"about_ca_system_score_gemma":0.0002115753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004897576,"about_ca_topic_score_gemma":0.0007079128,"domain_scores_codex":[0.999928,0.00001004195,0.000007382852,0.00001512201,0.00001656636,0.00002288154],"domain_scores_gemma":[0.9999418,0.000008859392,0.00001790048,0.000006734165,0.000004016662,0.00002067231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005119016,0.00003475719,0.00009066518,0.00002751779,0.000003217795,0.00003377623,0.000006410002,0.0000518137,0.998326,0.0000607213,0.00004639486,0.0008067964],"study_design_scores_gemma":[0.0000397546,0.0003493617,0.002709417,0.000005388951,0.000009210676,0.000097424,0.00001400718,0.0004857719,0.9948661,0.00004572533,0.001374759,0.000003038598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933164,0.00132961,0.002992686,0.0002419936,0.0001169064,0.00004010662,0.000635233,0.000091734,0.001235371],"genre_scores_gemma":[0.9907314,0.0009412803,0.003559334,0.0001443427,0.000028345,0.00006497919,0.0008420296,0.0000327419,0.003655556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00240187,"threshold_uncertainty_score":0.008035004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148317161411173,"score_gpt":0.2315389566605524,"score_spread":0.2100557850464407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}