{"id":"W3159831114","doi":"10.1016/j.jconrel.2021.04.034","title":"A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3′-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PTEN; Tensin; Phosphatase; Cancer research; In vivo; Synthetic lethality; Kinase; Pharmacology; Colorectal cancer; Cancer; Chemistry; DNA repair; Biology; Medicine; Phosphorylation; Biochemistry; Apoptosis; DNA; PI3K/AKT/mTOR pathway; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005485002,0.0002222313,0.000801853,0.0001091642,0.00005074073,0.00001112552,0.0002218643,0.0001564301,0.00007836349],"category_scores_gemma":[0.0009639029,0.0001762461,0.0005568989,0.0001592361,0.0001740572,0.000008543511,0.00005011608,0.0001763971,2.652038e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000580754,"about_ca_system_score_gemma":0.0008781099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004049938,"about_ca_topic_score_gemma":0.00001333294,"domain_scores_codex":[0.9979693,0.00008558512,0.001023151,0.0002440499,0.0003924975,0.0002854016],"domain_scores_gemma":[0.9971745,0.0001691826,0.0009762483,0.0002194832,0.001271393,0.0001891882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0154279,0.0005087318,0.000309171,0.00005599359,0.0006467924,0.00005623689,0.00006115848,0.001929594,0.9771398,0.00004673009,0.0004395008,0.003378421],"study_design_scores_gemma":[0.02349557,0.001625209,0.0003022439,0.0002551441,0.0001993448,0.00007529935,0.00009275138,0.0006937535,0.9705831,0.00001372557,0.002489343,0.0001745374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549143,0.04031372,0.003126037,0.0003854552,0.0006363451,0.000367028,0.0002221222,0.000003452956,0.00003149978],"genre_scores_gemma":[0.9965006,0.001321654,0.00143743,0.0001998823,0.0004220476,0.00002866798,0.00001860351,0.00003611587,0.00003505375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04158621,"threshold_uncertainty_score":0.7187107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009711410431529633,"score_gpt":0.2614885352308977,"score_spread":0.251777124799368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}