{"id":"W3159836411","doi":"10.1016/j.jcmgh.2021.04.017","title":"Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Israel Science Foundation; Abisch-Frenkel-Stiftung; International Development Research Centre","keywords":"Catabolism; Glucagon; Endocrinology; Internal medicine; CREB; Biology; Gluconeogenesis; Chromatin immunoprecipitation; Glucose homeostasis; Hormone; Corticosterone; Insulin; Gene expression; Biochemistry; Gene; Transcription factor; Metabolism; Insulin resistance; Medicine; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001761884,0.0003323702,0.0004953642,0.00008218993,0.0001615528,0.00003686086,0.000174865,0.0003357331,0.00002377727],"category_scores_gemma":[0.0001084745,0.0003471327,0.00009846632,0.00008466287,0.0002586293,0.000006807777,0.0003995823,0.0001647224,0.000006790454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007292801,"about_ca_system_score_gemma":0.00008324649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002046212,"about_ca_topic_score_gemma":0.0001035321,"domain_scores_codex":[0.9977866,0.0002358072,0.0003358938,0.0008749171,0.0001086716,0.000658083],"domain_scores_gemma":[0.9990091,0.00001018992,0.00008528703,0.0004185983,0.0001524571,0.0003244128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796118,0.00006286614,0.01018147,0.00004925101,0.0001514085,0.0003043758,0.00007684185,0.000004812585,0.9402134,0.0003172347,0.0001273753,0.04833137],"study_design_scores_gemma":[0.001123267,0.0004918335,0.003476742,0.00001528668,0.0001924625,0.0007331244,0.00007331269,0.00005750055,0.8909065,0.0001298151,0.1024661,0.0003340597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8486554,0.1396298,0.01086939,0.0003284616,0.0002652208,0.0001518236,0.00002994902,0.00001695443,0.00005296323],"genre_scores_gemma":[0.9771353,0.01588494,0.002395737,0.004055012,0.0001886188,0.00006351239,0.0001842555,0.00004136613,0.00005127484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1284799,"threshold_uncertainty_score":0.9998981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007363263246486751,"score_gpt":0.2183108710809025,"score_spread":0.2109476078344158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}