{"id":"W3159841217","doi":"10.1038/s41541-021-00322-7","title":"Quality by design modelling to support rapid RNA vaccine production against emerging infectious diseases","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC","funders":"Engineering and Physical Sciences Research Council; Research Councils UK; Department of Health and Social Care; UK Research and Innovation","keywords":"Quality by Design; Bioprocess; Critical quality attributes; Quality (philosophy); Computer science; Biochemical engineering; Computational biology; Automation; Production (economics); Biotechnology; Risk analysis (engineering); Engineering; Biology; Medicine; Operations management; Downstream (manufacturing)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002470927,0.001089576,0.0009369825,0.000825593,0.0003493851,0.001387402,0.0007712024,0.000980358,0.002554839],"category_scores_gemma":[0.003409761,0.0007375382,0.001650766,0.0005215684,0.0007455333,0.0006756046,0.0007642046,0.0009276174,0.0003927493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001462953,"about_ca_system_score_gemma":0.002090501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003712983,"about_ca_topic_score_gemma":0.003127804,"domain_scores_codex":[0.9991867,0.0003066285,0.00003951284,0.0001031089,0.0002758219,0.00008813594],"domain_scores_gemma":[0.9981821,0.001169063,0.0002634583,0.0001028021,0.0002391595,0.00004343749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00001487453,0.00001365603,0.0002252533,0.00006448508,0.00001112974,0.00001418572,0.00001579636,0.9901063,0.001943934,0.004594164,0.00006102305,0.002935271],"study_design_scores_gemma":[0.00001022587,0.00004398609,0.00007491917,0.000009168593,0.00001054642,0.000007392234,0.00000474711,0.9939626,0.0009530843,0.003996347,0.0009226512,0.000004386902],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02459948,0.0003216524,0.9694717,0.0001643039,0.00002522728,0.0001592105,0.0001933117,0.0002319017,0.004833145],"genre_scores_gemma":[0.5900291,0.0009278843,0.4025375,0.0001085283,0.00002308556,0.001022901,0.0004592108,0.0001941597,0.004697755],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003712983,"threshold_uncertainty_score":0.01306766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066712816541159,"score_gpt":0.292570713480631,"score_spread":0.2719035853152194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}