{"id":"W3159845336","doi":"10.1126/sciadv.abd2710","title":"Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"Signal transducing adaptor protein; Terminal (telecommunication); Biology; Cell biology; Computational biology; Signal transduction; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221568,0.00007074096,0.0001166104,0.00005107277,0.0001098526,0.00000953648,0.00009929825,0.00005258211,0.0001393371],"category_scores_gemma":[0.00003603534,0.00005914572,0.00002510469,0.0001992122,0.0004719796,0.0001430816,0.00006007353,0.00007129415,0.000008232429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001601271,"about_ca_system_score_gemma":0.0001054582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001161601,"about_ca_topic_score_gemma":0.00000856863,"domain_scores_codex":[0.9993425,0.0000342899,0.0001323973,0.00027495,0.00004056341,0.0001753274],"domain_scores_gemma":[0.9996578,0.000009527383,0.00009474138,0.0001233486,0.00009984095,0.00001474941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001708059,0.00003240586,0.0007705603,0.00002153836,0.000003357817,0.000001576231,0.0001242728,0.000001025369,0.989685,0.0001456187,0.000006392259,0.009191195],"study_design_scores_gemma":[0.0002567119,0.0001427337,0.007357489,0.00002274308,0.000008254256,0.00002310765,0.0002433323,0.00000575177,0.9901127,0.0004170879,0.001341011,0.00006907093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944828,0.004128045,0.0005080904,0.0001231967,0.0001846004,0.00008837775,0.000009563334,0.00000928954,0.0004660417],"genre_scores_gemma":[0.9985945,0.00006503496,0.0005990276,0.00004740354,0.000007596189,0.00001279516,0.000006976344,0.000002496348,0.0006642209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009122125,"threshold_uncertainty_score":0.2411892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006130330743347002,"score_gpt":0.238677924681085,"score_spread":0.232547593937738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}