{"id":"W3159886782","doi":"10.3390/biomedicines9050498","title":"Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Lung Foundation Australia; Raine Medical Research Foundation; U.S. Department of Veterans Affairs","keywords":"Suppressor of cytokine signaling 1; Idiopathic pulmonary fibrosis; STAT protein; Fibroblast; microRNA; Cancer research; Cytokine; Methylation; STAT3; SOCS3; Fibrosis; Biology; Chemistry; Signal transduction; Medicine; Lung; Cell biology; Pathology; Internal medicine; Immunology; Gene; Cell culture; Suppressor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006832404,0.000243149,0.0004199572,0.0001511436,0.0000573439,0.00001914841,0.00008130246,0.0001703295,0.0009334136],"category_scores_gemma":[0.0002067238,0.000155418,0.00006984953,0.0004527924,0.00009290775,0.0001597061,0.00005323655,0.0001550704,0.00002232617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055576,"about_ca_system_score_gemma":0.0001914285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000152562,"about_ca_topic_score_gemma":0.00001400726,"domain_scores_codex":[0.9981911,0.00007897858,0.0004079618,0.0004926925,0.0005423549,0.0002868787],"domain_scores_gemma":[0.9989808,0.0001231442,0.0001338537,0.0003079368,0.0002365587,0.0002177106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009271636,0.0006851276,0.01826224,0.000332748,0.00009225086,0.0001990467,0.0009019665,2.299554e-7,0.9377763,9.1905e-7,0.03043664,0.002040874],"study_design_scores_gemma":[0.01935107,0.006540242,0.3015685,0.01167985,0.0006327937,0.00002754601,0.0008671877,0.001608718,0.6297129,0.00005025944,0.02698929,0.0009716291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99414,0.0008870904,0.0001220877,0.003389125,0.0003120535,0.0005159474,0.000429163,0.00005959206,0.0001449717],"genre_scores_gemma":[0.9940626,0.00008463545,0.0007425322,0.001122569,0.0003102909,0.00004188982,0.002866514,0.00004059446,0.0007283775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3080634,"threshold_uncertainty_score":0.9999799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015461144477971,"score_gpt":0.2572235861771425,"score_spread":0.2470689747323628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}