{"id":"W3159886782","doi":"10.3390/biomedicines9050498","title":"Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Lung Foundation Australia; Raine Medical Research Foundation; U.S. Department of Veterans Affairs","keywords":"Suppressor of cytokine signaling 1; Idiopathic pulmonary fibrosis; STAT protein; Fibroblast; microRNA; Cancer research; Cytokine; Methylation; STAT3; SOCS3; Fibrosis; Biology; Chemistry; Signal transduction; Medicine; Lung; Cell biology; Pathology; Internal medicine; Immunology; Gene; Cell culture; Suppressor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468277,0.0002881907,0.0002567427,0.0003852223,0.0002071117,0.0002026507,0.0000907155,0.0002221036,0.00259178],"category_scores_gemma":[0.0003524614,0.0001246379,0.0002521163,0.0001418476,0.0002291241,0.0001124257,0.000108577,0.0002674415,0.0003084033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234424,"about_ca_system_score_gemma":0.0001003947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004676819,"about_ca_topic_score_gemma":0.0005821058,"domain_scores_codex":[0.9998584,0.00001853829,0.00002004023,0.00005009635,0.00002973417,0.00002322005],"domain_scores_gemma":[0.9998317,0.00003677318,0.00005483219,0.00001897223,0.00002023224,0.00003746194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001095781,0.00004378819,0.06711669,0.0001645508,0.00005622912,0.00184966,0.0003132675,0.00004526348,0.9203825,0.00008072382,0.0001638904,0.008687751],"study_design_scores_gemma":[0.00007245834,0.001025666,0.788956,0.00003054323,0.0001418222,0.0168636,0.0004228909,0.0004871673,0.1887603,0.0001763375,0.003042629,0.00002052387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978847,0.0006061235,0.0006636715,0.00004359863,0.00001340592,0.00001143222,0.0002566618,0.00002102952,0.0004992143],"genre_scores_gemma":[0.9990363,0.0001206516,0.0002863292,0.00002239064,0.00000494484,0.0000120595,0.0002201533,0.000004489636,0.0002925641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259178,"threshold_uncertainty_score":0.00867039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015461144477971,"score_gpt":0.2572235861771425,"score_spread":0.2470689747323628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}