{"id":"W3159905002","doi":"10.1016/j.jconrel.2021.04.023","title":"Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis","keywords":"Hepatocellular carcinoma; Cancer research; Genetic enhancement; Biology; Kinase; Gene; Programmed cell death; Biomarker; Gene expression; Immunology; Medicine; Apoptosis; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003206554,0.0001468878,0.0005491123,0.00005900827,0.0000520452,0.000008657347,0.000228076,0.0001113939,0.00002078722],"category_scores_gemma":[0.000129358,0.00009310426,0.0008031093,0.00008632742,0.00007799485,0.000003868553,0.00003671285,0.0000681204,5.581226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004881616,"about_ca_system_score_gemma":0.001136777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001120978,"about_ca_topic_score_gemma":0.00001854337,"domain_scores_codex":[0.9985819,0.0001970972,0.0005893978,0.0001473701,0.0002853741,0.0001987861],"domain_scores_gemma":[0.9982293,0.00003861004,0.00052807,0.0003811778,0.000722552,0.0001002773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02503078,0.0004788132,0.001425926,0.00003504367,0.0004986162,0.00003334001,0.00003232568,0.0001714542,0.9702575,0.000004094008,0.00009631339,0.00193582],"study_design_scores_gemma":[0.02126375,0.008281243,0.0002718387,0.00003111946,0.0001378073,0.00002934263,0.00003485468,0.0006434856,0.9683579,0.00004538161,0.0008212492,0.00008203375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910948,0.007370371,0.0002182866,0.0002655659,0.00008778584,0.0008905145,0.00003239499,8.034799e-7,0.00003946944],"genre_scores_gemma":[0.998044,0.0004030351,0.0003067685,0.00005188108,0.0002601595,0.00004736223,0.000007440602,0.00002147786,0.0008578449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00780243,"threshold_uncertainty_score":0.3796681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302348985182662,"score_gpt":0.2624832673062534,"score_spread":0.2494597774544268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}