{"id":"W3159905002","doi":"10.1016/j.jconrel.2021.04.023","title":"Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis","keywords":"Hepatocellular carcinoma; Cancer research; Genetic enhancement; Biology; Kinase; Gene; Programmed cell death; Biomarker; Gene expression; Immunology; Medicine; Apoptosis; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120478,0.0002116273,0.0001965554,0.000198318,0.00007738136,0.0001754731,0.0001332519,0.0001765348,0.0005604113],"category_scores_gemma":[0.00008105462,0.00005471227,0.0001567034,0.0001133766,0.0001965009,0.000164861,0.0001469561,0.0002603678,0.0001263737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002597346,"about_ca_system_score_gemma":0.0001827957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215015,"about_ca_topic_score_gemma":0.0003999248,"domain_scores_codex":[0.9999278,0.00001589629,0.000004274419,0.00001018162,0.00002795681,0.00001388704],"domain_scores_gemma":[0.999965,0.000008763506,0.00001267023,0.000003437587,0.000004569908,0.000005661497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008682036,0.00004479545,0.00009211982,0.00006330849,0.000004064843,0.00003388585,0.00001043603,0.0001545665,0.9961841,0.0001049005,0.00002062631,0.003200492],"study_design_scores_gemma":[0.00001290915,0.0006888364,0.00125656,0.00000428711,0.00001324203,0.0001917163,0.00001335075,0.0007259417,0.9957823,0.00003604094,0.001271609,0.000003205592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905888,0.004177484,0.004214008,0.00008523557,0.00002411349,0.00004863205,0.00007199218,0.00003026924,0.000759556],"genre_scores_gemma":[0.994261,0.002325923,0.001986992,0.00001771193,0.000006861826,0.0000239477,0.00008807369,0.00000728751,0.001282158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005604113,"threshold_uncertainty_score":0.00188446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302348985182662,"score_gpt":0.2624832673062534,"score_spread":0.2494597774544268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}