{"id":"W3159929043","doi":"10.1038/s41598-021-88386-2","title":"CpG-ODN induced antimicrobial immunity in neonatal chicks involves a substantial shift in serum metabolic profiles","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Alberta; University of Saskatchewan","funders":"Western Economic Diversification Canada; Genome Alberta; Canada Foundation for Innovation; Chicken Farmers of Saskatchewan; Alberta Livestock and Meat Agency; Natural Sciences and Engineering Research Council of Canada; Canadian Poultry Research Council","keywords":"Immune system; CpG Oligodeoxynucleotide; Betaine; Choline; Immunity; Innate immune system; Biology; Internal medicine; Chemistry; Endocrinology; Biochemistry; Immunology; Medicine; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040498,0.0002577618,0.0002530574,0.0001795487,0.00007719696,0.0001427783,0.00008682219,0.0002484058,0.0006323527],"category_scores_gemma":[0.0001266534,0.0001341102,0.0001649497,0.00008434021,0.0002095272,0.0001418464,0.0001345824,0.0004673198,0.0001134157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147311,"about_ca_system_score_gemma":0.0002018565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158732,"about_ca_topic_score_gemma":0.002379126,"domain_scores_codex":[0.9999189,0.000009356661,0.000007682544,0.00002609476,0.00002039358,0.00001756961],"domain_scores_gemma":[0.9998767,0.00001158033,0.00004708955,0.000006394716,0.00002500034,0.00003312314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001915789,0.000008502627,0.0004837273,0.0000243202,0.000002872258,0.0000119717,0.000009894234,0.00001302183,0.9987832,0.000007086414,0.00000754196,0.0004563084],"study_design_scores_gemma":[0.00001147907,0.00123754,0.05068673,0.00001152598,0.00002295843,0.0001140921,0.00009102394,0.000384712,0.9466366,0.0000216632,0.000773508,0.000008147525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962988,0.0009427374,0.001572311,0.00005108005,0.00002091941,0.00002389548,0.0005313554,0.00002480315,0.0005341585],"genre_scores_gemma":[0.9933884,0.000749458,0.002848125,0.0001342765,0.000006040084,0.00006285893,0.0007345523,0.00001122524,0.002065029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158732,"threshold_uncertainty_score":0.002303958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422484120398111,"score_gpt":0.2411798320633235,"score_spread":0.2269549908593423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}