{"id":"W3160000230","doi":"10.1101/2021.05.11.443660","title":"Engineered type six secretion systems deliver active exogenous effectors and Cre recombinase","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Type VI secretion system; Recombinase; Effector; Biology; Vibrio cholerae; Secretion; Cre recombinase; Synthetic biology; Computational biology; Pseudomonas aeruginosa; Chaperone (clinical); Escherichia coli; Cell biology; Gene; Genetics; Bacteria; Transgene; Virulence; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004012392,0.0004540544,0.0002760394,0.0002896393,0.0001298213,0.0006842991,0.0004407861,0.000616146,0.00105472],"category_scores_gemma":[0.0002933354,0.0002619108,0.0004599184,0.0002085333,0.0002859544,0.0004261979,0.0004121857,0.0008295627,0.0008759538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190419,"about_ca_system_score_gemma":0.0002234897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002988577,"about_ca_topic_score_gemma":0.0002486432,"domain_scores_codex":[0.9996531,0.00006740305,0.00005903247,0.000050018,0.0001214176,0.00004909297],"domain_scores_gemma":[0.9996504,0.00004711415,0.0001626714,0.00005800591,0.00004149111,0.00004043538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003998202,0.00002197423,0.000146942,0.00004389859,0.000008456313,0.00004141093,0.00001212533,0.0001826931,0.9978443,0.0003951808,0.00005389633,0.001209176],"study_design_scores_gemma":[0.00001632815,0.0001249771,0.0002825698,0.000006804496,0.00001132394,0.0001851319,0.00001045295,0.001059199,0.9941856,0.00006699925,0.004043614,0.000006899942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9042231,0.0013864,0.08975055,0.0003775347,0.0002168406,0.0002045929,0.0008760185,0.0007021163,0.002262739],"genre_scores_gemma":[0.956605,0.000802857,0.03588043,0.0001103046,0.00002140845,0.00008344013,0.001115284,0.000121505,0.005259707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105472,"threshold_uncertainty_score":0.003528416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045908533936554,"score_gpt":0.2204655094159769,"score_spread":0.2100064240766113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}