{"id":"W3160042726","doi":"10.1038/s41598-021-99838-0","title":"The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Research Centre of Canada; Discovery Centre; University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Immune system; Transcriptome; Innate immune system; Candida albicans; Interferon; Signal transduction; Toll-like receptor; Microarray analysis techniques; Candida tropicalis; Pattern recognition receptor; Receptor; Immunology; Computational biology; Gene; Microbiology; Cell biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004781332,0.0002686972,0.0004035333,0.0006480325,0.0002304959,0.0007203357,0.0001748552,0.000248201,0.000501402],"category_scores_gemma":[0.0002897907,0.000183975,0.0003702485,0.0005404348,0.0002014704,0.0004629622,0.0004182778,0.0003500196,0.0001489528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735062,"about_ca_system_score_gemma":0.0004000251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006295971,"about_ca_topic_score_gemma":0.001020414,"domain_scores_codex":[0.9996839,0.00008590119,0.00001651201,0.00009327767,0.00006672628,0.00005367071],"domain_scores_gemma":[0.9998499,0.00004279035,0.00003860466,0.00001454468,0.00003436053,0.00001979099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004596275,0.00006491291,0.05779337,0.000686678,0.000298898,0.0002135056,0.0003422839,0.002772411,0.9023396,0.001188673,0.0003306737,0.03350929],"study_design_scores_gemma":[0.00004420685,0.0004968616,0.7866488,0.0002144852,0.001044484,0.000763104,0.001399523,0.03654177,0.152107,0.005066823,0.01559391,0.00007908988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719781,0.008841831,0.014127,0.0003206681,0.00004117486,0.00005315678,0.001935345,0.000141693,0.002561141],"genre_scores_gemma":[0.988095,0.003071546,0.006786965,0.0002164775,0.00002649255,0.00004881004,0.001071924,0.00002124273,0.0006615661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007203357,"threshold_uncertainty_score":0.002528667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494308504019285,"score_gpt":0.270052369437133,"score_spread":0.2551092843969401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}