{"id":"W3160051799","doi":"10.1111/hae.14329","title":"Comparison of single subject and population‐based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; University of Waterloo","funders":"Octapharma","keywords":"Medicine; Dosing; Pharmacokinetics; Haemophilia; Population; Intraclass correlation; Trough level; Therapeutic drug monitoring; Haemophilia A; Internal medicine; Surgery; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002914079,0.0003462558,0.0006645293,0.0003206264,0.0001268768,0.0005265735,0.0001848022,0.0004256697,0.0009299878],"category_scores_gemma":[0.004902764,0.0001474148,0.0003997923,0.0003358731,0.0002124791,0.0002471831,0.0002045375,0.0003011812,0.0002162441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132364,"about_ca_system_score_gemma":0.0002301301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003018507,"about_ca_topic_score_gemma":0.0001996284,"domain_scores_codex":[0.9983885,0.0008597815,0.00009834151,0.0003935563,0.000214121,0.0000457399],"domain_scores_gemma":[0.9972193,0.00135325,0.0007189704,0.000296724,0.0002669964,0.0001447157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03093479,0.00124309,0.8590183,0.0003117226,0.00151795,0.0001364664,0.0007088055,0.005920903,0.01816974,0.0001952734,0.0009324008,0.08091056],"study_design_scores_gemma":[0.0005852729,0.02710539,0.9467399,0.00002557176,0.0004231014,0.000559018,0.0002385812,0.01656236,0.006319097,0.0002027207,0.001195604,0.00004335805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997555,0.0003267869,0.001671427,0.0000160681,0.00000943153,0.00004844887,0.0001562481,0.00002792896,0.0001888828],"genre_scores_gemma":[0.9987454,0.00006772209,0.0008452771,0.00001086219,0.000008642723,0.00004186331,0.000158656,0.000003986151,0.0001174581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002914079,"threshold_uncertainty_score":0.01541132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04134673015416726,"score_gpt":0.3336121275155076,"score_spread":0.2922653973613403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}