{"id":"W3160052401","doi":"10.1208/s12248-021-00599-5","title":"Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine","year":2021,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto; SickKids Foundation; Hospital for Sick Children; University of Waterloo","funders":"","keywords":"Breastfeeding; Breast milk; Lamotrigine; Pharmacokinetics; Medicine; Breast feeding; Workflow; Obstetrics; Pediatrics; Pharmacology; Epilepsy; Computer science; Psychiatry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001554128,0.0002776711,0.0004615433,0.00006029506,0.0004086398,0.0001111444,0.0002889088,0.00007715652,0.0005336606],"category_scores_gemma":[0.0003492335,0.0001571229,0.00008755285,0.0007622822,0.00005941062,0.0001323673,0.0001970438,0.0008671451,0.00004630176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136057,"about_ca_system_score_gemma":0.0002055097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003594773,"about_ca_topic_score_gemma":0.000005960575,"domain_scores_codex":[0.9974778,0.0002508517,0.0006235498,0.0004144672,0.0007529127,0.0004803635],"domain_scores_gemma":[0.9981657,0.0002700856,0.0002159425,0.000305987,0.0004245489,0.0006176907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01964642,0.001240331,0.02417531,0.0002950027,0.00156468,0.00058936,0.002923297,0.428497,0.4164827,0.0003313682,0.00226016,0.1019944],"study_design_scores_gemma":[0.03683649,0.007817809,0.4139271,0.006857034,0.005671437,0.02016865,0.001782051,0.4466359,0.03184469,0.009557421,0.01580462,0.003096773],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.850189,0.0001531289,0.0803187,0.0668636,0.00024456,0.0007737387,0.00001849088,0.0000813539,0.001357476],"genre_scores_gemma":[0.9745697,0.00004934599,0.01618944,0.008331069,0.0007288833,0.00005813798,0.00001008741,0.00002824407,0.00003511069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3897518,"threshold_uncertainty_score":0.6407287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02926719251959968,"score_gpt":0.308371838287481,"score_spread":0.2791046457678814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}