{"id":"W3160088467","doi":"10.3389/fgene.2021.767341","title":"Transcriptome Analysis Reveals Higher Levels of Mobile Element-Associated Abnormal Gene Transcripts in Temporal Lobe Epilepsy Patients","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Epilepsy; Hippocampal sclerosis; Transcriptome; Biology; Temporal lobe; Gene; Genetics; Mobile genetic elements; RNA splicing; Intron; Computational biology; Genome; Gene expression; Neuroscience; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006049752,0.0001081701,0.0002172528,0.0003312429,0.00014436,0.0002664725,0.00004939334,0.0001602265,0.001172564],"category_scores_gemma":[0.0002714107,0.00006782003,0.0002077369,0.000343762,0.0001003932,0.00009678573,0.0001494407,0.0001827407,0.0002225256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008778206,"about_ca_system_score_gemma":0.00007846049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459743,"about_ca_topic_score_gemma":0.000846788,"domain_scores_codex":[0.9999324,0.000006474399,0.000007867987,0.00002740478,0.00001107195,0.00001476792],"domain_scores_gemma":[0.9999068,0.00002215974,0.00003352185,0.000006214007,0.00001579745,0.00001549404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001848288,0.00006581439,0.4449664,0.0002203759,0.0002432117,0.002616847,0.0009137933,0.0003532572,0.5251542,0.0001505276,0.00114161,0.02232569],"study_design_scores_gemma":[0.00001368449,0.0001443617,0.9848177,0.000014503,0.00007208384,0.00238532,0.0004358194,0.0006224001,0.009518371,0.0001769918,0.00178676,0.00001221657],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973671,0.0003252691,0.0003196015,0.00003683978,0.000005025568,0.00000432757,0.001659662,0.000012947,0.000269278],"genre_scores_gemma":[0.9942213,0.0003338777,0.0005111466,0.00007939922,0.000009777385,0.00002006352,0.004310976,0.00001299057,0.0005005569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172564,"threshold_uncertainty_score":0.003922641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126391933788602,"score_gpt":0.2334849962394387,"score_spread":0.2222210769015526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}