{"id":"W3160088467","doi":"10.3389/fgene.2021.767341","title":"Transcriptome Analysis Reveals Higher Levels of Mobile Element-Associated Abnormal Gene Transcripts in Temporal Lobe Epilepsy Patients","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Epilepsy; Hippocampal sclerosis; Transcriptome; Biology; Temporal lobe; Gene; Genetics; Mobile genetic elements; RNA splicing; Intron; Computational biology; Genome; Gene expression; Neuroscience; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003765982,0.0002473923,0.0005654283,0.0002358513,0.00003313164,0.00001613989,0.0002835948,0.0003263802,0.0001124481],"category_scores_gemma":[0.00003171571,0.0002772982,0.0002659367,0.0007468459,0.00005742887,0.000006984875,0.00004557699,0.0001139025,0.000001031131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005556576,"about_ca_system_score_gemma":0.00009194107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002774519,"about_ca_topic_score_gemma":0.0001350646,"domain_scores_codex":[0.9977077,0.0003064825,0.000748523,0.0004991511,0.0003005621,0.0004375728],"domain_scores_gemma":[0.9991262,0.000007828015,0.0001869516,0.0004358664,0.0001522672,0.00009090919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006252874,0.0003219074,0.4992743,0.00002190306,0.0003358846,0.00001066876,0.0001532446,0.0006614979,0.4966289,0.000004876326,0.0003404556,0.002183865],"study_design_scores_gemma":[0.001721466,0.0003137248,0.3155989,0.00002810395,0.0001989162,4.967552e-7,0.0001356586,0.000093672,0.6786751,0.0001906766,0.002695543,0.000347798],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852356,0.004474062,0.008865291,0.00002432543,0.0005391416,0.0003619391,0.0003490922,0.000006476825,0.000144112],"genre_scores_gemma":[0.9853805,0.0005962797,0.01275202,0.0001168105,0.00004153997,0.00006441038,0.0004594196,0.00003353058,0.0005555018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1836755,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126391933788602,"score_gpt":0.2334849962394387,"score_spread":0.2222210769015526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}