{"id":"W3160109437","doi":"10.1101/2021.05.14.444202","title":"Chromatin accessibility of primary human cancers ties regional mutational processes with tissues of origin","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Government of Ontario; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Biology; Mutagenesis; Cancer; Genetics; Epigenome; Chromatin; Epigenetics; Mutation; Germline mutation; Computational biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452372,0.0001906137,0.0001964653,0.0001894519,0.0001026534,0.0003825338,0.0002298442,0.0001672325,0.002351079],"category_scores_gemma":[0.0004682127,0.0001286231,0.0003835853,0.0002671492,0.0001982577,0.0001475298,0.0002424244,0.0001634898,0.0003208255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004152255,"about_ca_system_score_gemma":0.0002872536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006704251,"about_ca_topic_score_gemma":0.004609657,"domain_scores_codex":[0.9999276,0.00001626972,0.000002471063,0.00003424026,0.000008618206,0.00001078408],"domain_scores_gemma":[0.9998652,0.00005253725,0.00002707971,0.00002540647,0.0000154273,0.00001441739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0004460595,0.00006670997,0.1815247,0.0002102287,0.0002832393,0.0002692664,0.000192175,0.6731763,0.117315,0.006518373,0.000783491,0.01921432],"study_design_scores_gemma":[0.00004086352,0.0003822372,0.2750094,0.00002756011,0.0002089236,0.0005954092,0.0001965838,0.6715491,0.03247936,0.01346136,0.006001464,0.00004768271],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684281,0.0004226574,0.02697991,0.00004647277,0.000007083842,0.00002069725,0.00196542,0.0001910074,0.001938775],"genre_scores_gemma":[0.9968773,0.0001587482,0.001736089,0.00001010441,0.000001363142,0.00001261747,0.0007152997,0.00001840267,0.00047008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006704251,"threshold_uncertainty_score":0.01333046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713062316804841,"score_gpt":0.2516622815502,"score_spread":0.2345316583821516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}