{"id":"W3160112606","doi":"10.1172/jci147878","title":"Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Memorial Sloan-Kettering Cancer Center; Associazione Italiana per la Ricerca sul Cancro; Urology Care Foundation; College of Veterinary Medicine, Cornell University; MetLife Foundation; Damon Runyon Cancer Research Foundation; National Cancer Institute; Prostate Cancer Foundation; Weill Cornell Medical College; U.S. Department of Defense","keywords":"Prostate cancer; Cancer; Disease; Natural history; Biology; Prostate; Pathology; Medicine; Computational biology; Cancer research; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840442,0.00009986441,0.0006385823,0.00008355291,0.00002109747,0.00001371426,0.00005228421,0.0001105528,0.00001725008],"category_scores_gemma":[0.002501505,0.00006699212,0.0001702363,0.0002500223,0.0003643792,0.0001174426,0.00005244408,0.0005247774,9.420174e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005376458,"about_ca_system_score_gemma":0.00169708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001149445,"about_ca_topic_score_gemma":0.00001385887,"domain_scores_codex":[0.9972779,0.0003422872,0.001626284,0.0001894133,0.0004179709,0.0001461954],"domain_scores_gemma":[0.9977625,0.0004376128,0.0007840876,0.0001278476,0.0006122137,0.0002757103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001148378,0.0003901954,0.9470279,0.0002466819,0.00007947524,0.0006427637,0.00006708477,0.000002499691,0.008085889,0.00003945782,0.0001498297,0.04211984],"study_design_scores_gemma":[0.004602822,0.00121502,0.9738941,0.001452568,0.0001317706,0.00005936107,0.00003668366,0.00009477862,0.01675799,0.001473248,0.0002155066,0.00006618907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909219,0.004983742,0.00000914399,0.003464035,0.0002442895,0.0002287197,0.000006770291,0.000004729091,0.000136725],"genre_scores_gemma":[0.9935104,0.003081584,0.002673859,0.0004065278,0.0002137671,0.000006519909,0.00002117987,0.00001315772,0.00007296629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04205365,"threshold_uncertainty_score":0.3010547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09844316615881343,"score_gpt":0.4365089869987043,"score_spread":0.3380658208398909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}