{"id":"W3160113890","doi":"10.3389/fonc.2021.626187","title":"Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação Oswaldo Cruz; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Cancer research; Cervical cancer; microRNA; Adenocarcinoma; Transcription factor; Human papillomavirus; Cervix; Gene; Downregulation and upregulation; Biology; Oncology; Medicine; Cancer; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187463,0.0001539573,0.0003326201,0.0001067062,0.0000368829,0.000005621084,0.0001647666,0.0003554944,0.00001959979],"category_scores_gemma":[0.00002370954,0.0001414024,0.00009314838,0.0001876054,0.0001494453,0.0000048128,0.0001491561,0.000230197,6.498132e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069999,"about_ca_system_score_gemma":0.000132175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478179,"about_ca_topic_score_gemma":0.000778673,"domain_scores_codex":[0.9984879,0.0003913355,0.0003684404,0.0003513026,0.0001411479,0.0002599111],"domain_scores_gemma":[0.9994037,0.00001729192,0.0001415208,0.0003017825,0.00008587055,0.0000499006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002591739,0.0002103081,0.03400534,0.00007634475,0.00002023145,0.00002176812,0.0003509935,0.0005722372,0.9597734,0.00006942375,0.000108467,0.004532309],"study_design_scores_gemma":[0.001952749,0.0006931293,0.2404211,0.00002032499,0.00001696917,0.0000104546,0.00027607,0.0009207381,0.7551985,0.0002048743,0.0001681264,0.0001168786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771519,0.005221461,0.01657316,0.00006849871,0.0003710598,0.0003592729,0.00004825809,0.000002548608,0.0002038043],"genre_scores_gemma":[0.9991702,0.0002351336,0.0002501263,0.00004710478,0.00004650234,0.00002843295,0.00009932629,0.00002063811,0.0001024953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2064158,"threshold_uncertainty_score":0.5766221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143585952669459,"score_gpt":0.2524510573188062,"score_spread":0.2410151977921116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}