{"id":"W3160162735","doi":"10.1161/strokeaha.121.034747","title":"Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis","year":2021,"lang":"en","type":"article","venue":"Stroke","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Perelman School of Medicine, University of Pennsylvania; St George's University Hospitals NHS Foundation Trust; Biocenter, University of Oulu; NIHR Cambridge Biomedical Research Centre; Oulun Yliopisto; Medical Research Council; London School of Hygiene and Tropical Medicine; University of Texas Health Science Center at Houston; University of Cambridge; British Heart Foundation; Wellcome Trust; Brody School of Medicine; National Institute on Minority Health and Health Disparities; University of Pennsylvania; Imperial College London; Division of Mathematical Sciences; Fogarty International Center; East Carolina University; Novo Nordisk; National Institute for Health and Care Research; Cambridge University Hospitals; U.S. Department of Veterans Affairs","keywords":"Mendelian randomization; Medicine; Odds ratio; Demography; Genome-wide association study; Stroke (engine); Type 2 diabetes; Genetics; Population; Single-nucleotide polymorphism; Internal medicine; Genotype; Diabetes mellitus; Biology; Endocrinology; Environmental health; Gene; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06236919,0.001739493,0.003612552,0.002595266,0.0009135015,0.001234511,0.002010085,0.001852449,0.004267254],"category_scores_gemma":[0.109924,0.0008398811,0.005318223,0.003105818,0.001408507,0.0009550619,0.001129492,0.001274997,0.0003473325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008246373,"about_ca_system_score_gemma":0.00132526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003894218,"about_ca_topic_score_gemma":0.001712382,"domain_scores_codex":[0.9006139,0.08504643,0.002664705,0.007161851,0.003561828,0.0009512273],"domain_scores_gemma":[0.9487236,0.03769343,0.004226625,0.007789866,0.00122299,0.0003435116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06306337,0.0009860517,0.5267283,0.00288426,0.1275336,0.004063302,0.001444022,0.03760085,0.004885204,0.04884241,0.009562789,0.1724059],"study_design_scores_gemma":[0.02309726,0.009560139,0.2096827,0.0009467729,0.06705441,0.005740073,0.0005147923,0.5536049,0.003687226,0.1108109,0.01475593,0.0005448923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5011108,0.008128201,0.4795265,0.001234783,0.0005728304,0.00378481,0.001939012,0.001153356,0.002549755],"genre_scores_gemma":[0.8787981,0.001039759,0.1145569,0.0002687094,0.0001101446,0.003524555,0.000827186,0.0001222107,0.000752606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06236919,"threshold_uncertainty_score":0.3298437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01284083193749192,"score_gpt":0.2668534644278026,"score_spread":0.2540126324903107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}