{"id":"W3160169558","doi":"10.3389/fgene.2021.671866","title":"DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute on Minority Health and Health Disparities; U.S. National Library of Medicine; Fred and Pamela Buffett Cancer Center; Russian Science Foundation; Nebraska Department of Health and Human Services; Queen's University; Cardiff University; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Genetics; Mutagenesis; DNA methylation; Gene; DNA repair; Mutation; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001897461,0.0001604792,0.0001966581,0.0001899032,0.00004569898,0.00002737956,0.00007191723,0.0001540824,0.000006247823],"category_scores_gemma":[0.00004957117,0.000172281,0.000024487,0.0002852844,0.00005855483,0.000004206845,0.00005268805,0.0000562922,2.349001e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002069,"about_ca_system_score_gemma":0.0001585061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002082868,"about_ca_topic_score_gemma":0.004671983,"domain_scores_codex":[0.9987976,0.0001467148,0.0003117423,0.0004241519,0.0001074355,0.0002123577],"domain_scores_gemma":[0.9995759,0.00002218618,0.00005963903,0.0001721174,0.00008958703,0.00008055255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002947425,0.00005589023,0.2710195,0.00002872506,0.00001487965,0.000004305654,0.0005925496,0.01871072,0.6518698,0.000008361786,0.00001690673,0.05764887],"study_design_scores_gemma":[0.0009048854,0.00004635232,0.1732296,0.00003057021,0.00001841961,6.497257e-7,0.0003071476,0.003219348,0.8189992,0.0002911869,0.002735033,0.0002175536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668186,0.02046818,0.01195756,0.0002261602,0.0001725858,0.0002546757,0.00002504232,0.000003529583,0.00007371195],"genre_scores_gemma":[0.9706852,0.009020043,0.01988473,0.0001105213,0.00003751295,0.00009869025,0.00002927452,0.00002781445,0.0001061653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1671294,"threshold_uncertainty_score":0.7025415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174890382424513,"score_gpt":0.2545892787928165,"score_spread":0.2428403749685714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}