{"id":"W3160180364","doi":"10.1161/circ.142.suppl_3.16473","title":"Abstract 16473: Loss of the Apelin-Apelin Receptor Signaling Axis Worsens Hemodynamic Alterations and Right Ventricular (rv) Adaptation and Abrogates 17ß-Estradiol (E2)-Mediated Protection in Experimental Pulmonary Arterial Hypertension (PAH)","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Apelin; Medicine; Enos; Internal medicine; Endocrinology; Hemodynamics; Gene knockdown; Receptor; Western blot; Chemistry; Nitric oxide; Nitric oxide synthase; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002508598,0.0001684899,0.000259731,0.0001452839,0.000128142,0.00002716067,0.00005364647,0.0002214494,0.0001186521],"category_scores_gemma":[0.0003905189,0.0001335053,0.00006199367,0.000478881,0.0001647808,0.0001728677,0.00003573976,0.0003533844,0.00001368809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001270726,"about_ca_system_score_gemma":0.0001002002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009281075,"about_ca_topic_score_gemma":0.000006453775,"domain_scores_codex":[0.998302,0.0001240129,0.0005182731,0.0003753553,0.0004722063,0.0002081581],"domain_scores_gemma":[0.9992771,0.0001202346,0.0001693889,0.0001380611,0.000125861,0.0001693759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003261774,0.000200283,0.003792468,0.0001163084,0.00003188783,0.00006410169,0.0006012838,0.001073378,0.9915435,0.00000880905,0.00001437162,0.002227447],"study_design_scores_gemma":[0.002585297,0.0001724461,0.3680826,0.0004488273,0.00006912677,0.0001371949,0.0006005429,0.5903466,0.0371919,0.00008670417,0.0000748494,0.0002038854],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953437,0.0004708921,0.0007076983,0.002015019,0.0001258372,0.001264561,0.00001500902,0.0000392759,0.00001795286],"genre_scores_gemma":[0.9990886,0.00005064503,0.0002111078,0.00009866938,0.0002011987,0.00003527947,0.0002886602,0.00002283423,0.000003022729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9543516,"threshold_uncertainty_score":0.5444188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03148902616842222,"score_gpt":0.2553597907521933,"score_spread":0.2238707645837711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}