{"id":"W3160180364","doi":"10.1161/circ.142.suppl_3.16473","title":"Abstract 16473: Loss of the Apelin-Apelin Receptor Signaling Axis Worsens Hemodynamic Alterations and Right Ventricular (rv) Adaptation and Abrogates 17ß-Estradiol (E2)-Mediated Protection in Experimental Pulmonary Arterial Hypertension (PAH)","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Apelin; Medicine; Enos; Internal medicine; Endocrinology; Hemodynamics; Gene knockdown; Receptor; Western blot; Chemistry; Nitric oxide; Nitric oxide synthase; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002516569,0.0006896543,0.0008933413,0.0004267736,0.0002974019,0.000385256,0.0003280209,0.0006602039,0.007145536],"category_scores_gemma":[0.0001385236,0.0002583885,0.0004597536,0.0002455396,0.0005511882,0.0004394393,0.0002459135,0.001874056,0.001409304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050542,"about_ca_system_score_gemma":0.0002748585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003787599,"about_ca_topic_score_gemma":0.0004004387,"domain_scores_codex":[0.9996603,0.00004523573,0.00004319034,0.00007115893,0.00008116676,0.000099027],"domain_scores_gemma":[0.99976,0.00002239031,0.00005571601,0.00002334903,0.00001612055,0.0001225721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002327419,0.0003862083,0.0003073394,0.000118859,0.00003148942,0.0002085775,0.00002569408,0.00004292792,0.9921045,0.0001038385,0.0003519756,0.003991161],"study_design_scores_gemma":[0.0005444416,0.007953144,0.02028394,0.00003924595,0.0001560266,0.001200335,0.0001734024,0.0009773171,0.9614642,0.0001407329,0.007045141,0.00002218598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886878,0.003251375,0.002759435,0.0005057525,0.0003972729,0.00008023743,0.001362472,0.0003230027,0.002632572],"genre_scores_gemma":[0.9788443,0.002604548,0.002366413,0.0003997435,0.0002216124,0.0002886756,0.001785003,0.00009678205,0.01339285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007145536,"threshold_uncertainty_score":0.02390414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03148902616842222,"score_gpt":0.2553597907521933,"score_spread":0.2238707645837711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}