{"id":"W3160325452","doi":"10.1186/s13059-021-02339-6","title":"Functional mapping of androgen receptor enhancer activity","year":2021,"lang":"en","type":"article","venue":"Genome biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Astellas Pharma; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; KWF Kankerbestrijding; Astellas Foundation for Research on Metabolic Disorders; Prostate Cancer Foundation","keywords":"Enhancer; Biology; Androgen receptor; Enhancer RNAs; Promoter; Transcription factor; Gene; Binding site; Regulation of gene expression; Regulatory sequence; Genetics; Transcription (linguistics); Gene expression; Molecular biology; Prostate cancer; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000707763,0.00005578626,0.0001697857,0.00004815367,0.00003021636,0.000001672618,0.00002370981,0.00006968262,0.002249414],"category_scores_gemma":[0.00002303992,0.00004295115,0.00005542376,0.000133788,0.00007852652,0.00001470011,0.00004152222,0.0000752487,0.00007599362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006724161,"about_ca_system_score_gemma":0.0002775393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001040768,"about_ca_topic_score_gemma":0.000001847466,"domain_scores_codex":[0.9994954,0.00003829338,0.00008481863,0.0001678802,0.0000561171,0.0001574504],"domain_scores_gemma":[0.9996563,0.00002870485,0.00002933362,0.0001238812,0.0001096771,0.00005214314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898694,0.00007992434,0.01183188,0.00003564998,0.0001442616,0.000009602812,0.00009646879,2.86917e-7,0.9767064,0.0000569681,0.0003218173,0.01052689],"study_design_scores_gemma":[0.001710058,0.000332995,0.111637,0.00002029445,0.00002683545,0.00003737415,0.00009907472,0.000003238187,0.7259756,0.0001782039,0.1598917,0.00008762006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991617,0.00388819,0.000311466,0.001040554,0.0001854338,0.0001089993,0.00003938192,0.00001259528,0.002796342],"genre_scores_gemma":[0.9924236,0.0007222703,0.0003702613,0.00007146036,0.0002034303,0.00001958938,0.0002081126,0.00000607764,0.005975222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2507308,"threshold_uncertainty_score":0.9986627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0575315143107429,"score_gpt":0.3209653406788414,"score_spread":0.2634338263680985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}