{"id":"W3160370392","doi":"10.1038/s41467-021-23232-7","title":"Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto; McMaster University","funders":"Hospital for Sick Children","keywords":"Dexamethasone; Drug delivery; Drug; Pharmacokinetics; Controlled release; Implant; Pharmacology; Corticosteroid; Medicine; Biomedical engineering; Chemistry; Materials science; Nanotechnology; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745445,0.0004228542,0.0002565878,0.0003121408,0.000173734,0.0004492429,0.0002717317,0.0004016284,0.001867046],"category_scores_gemma":[0.0001834364,0.0001654534,0.0002365737,0.0001774067,0.000223427,0.0003237249,0.0002262984,0.0004250403,0.0007004451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139716,"about_ca_system_score_gemma":0.000349997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003098123,"about_ca_topic_score_gemma":0.0006093938,"domain_scores_codex":[0.9998007,0.00001780902,0.00001294507,0.00003344865,0.0001111674,0.00002386292],"domain_scores_gemma":[0.9998847,0.00001833412,0.00004529117,0.0000145238,0.00001501035,0.00002211639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005804193,0.00002502058,0.00003114093,0.00004643726,0.000002415245,0.00004334415,0.000008640502,0.00007050736,0.995583,0.0001137023,0.00004845461,0.003969437],"study_design_scores_gemma":[0.00003070026,0.0006272863,0.000571421,0.000008928747,0.00001257376,0.0003264585,0.00001030308,0.0008334735,0.9927296,0.00005267798,0.004786081,0.00001059271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8998796,0.01487484,0.07446042,0.0002721916,0.0003955486,0.0005240649,0.0003773523,0.0006263512,0.008589658],"genre_scores_gemma":[0.9625008,0.003315012,0.02647567,0.00008779268,0.00004350922,0.00009450676,0.0001683737,0.00006902825,0.007245478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001867046,"threshold_uncertainty_score":0.006245911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204716859803545,"score_gpt":0.2864816188506032,"score_spread":0.2744344502525677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}