{"id":"W3160370392","doi":"10.1038/s41467-021-23232-7","title":"Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto; McMaster University","funders":"Hospital for Sick Children","keywords":"Dexamethasone; Drug delivery; Drug; Pharmacokinetics; Controlled release; Implant; Pharmacology; Corticosteroid; Medicine; Biomedical engineering; Chemistry; Materials science; Nanotechnology; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372866,0.0001182732,0.0003307298,0.0000554371,0.0002183567,0.0000313882,0.0002702105,0.0001647193,0.00002427534],"category_scores_gemma":[0.0004156141,0.0001040713,0.0001273024,0.0001308833,0.00005942352,0.00006327539,0.0002656769,0.0004606567,0.000004700846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003305578,"about_ca_system_score_gemma":0.0001854495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002155182,"about_ca_topic_score_gemma":0.0005998113,"domain_scores_codex":[0.9992031,0.00008305394,0.0002165334,0.0001692324,0.0001234147,0.0002046149],"domain_scores_gemma":[0.9971812,0.0005211278,0.00007051202,0.001731249,0.000380737,0.000115117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00697801,0.003075735,0.3021354,0.0005340818,0.004628875,0.0002268516,0.003357787,9.529745e-7,0.4979002,0.07983211,0.06846438,0.0328656],"study_design_scores_gemma":[0.1316691,0.000656752,0.2153314,0.0007564951,0.006086315,0.0004861343,0.01123908,0.003523231,0.1141733,0.003844557,0.5103592,0.00187446],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8205112,0.1391152,0.00008068845,0.03698002,0.0001610311,0.0009292321,0.0001138146,0.00007796747,0.002030839],"genre_scores_gemma":[0.9900144,0.002225098,0.002121791,0.002928445,0.0000400345,0.00007679484,0.0002676715,0.00002053641,0.002305205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4418948,"threshold_uncertainty_score":0.4243905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204716859803545,"score_gpt":0.2864816188506032,"score_spread":0.2744344502525677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}