{"id":"W3160401327","doi":"10.1101/2021.05.12.443793","title":"Mycolactone enhances the Ca <sup>2+</sup> leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca <sup>2+</sup> permeable state","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Universität des Saarlandes; Weill Cornell Medical College; Deutsche Forschungsgemeinschaft; Wellcome Trust; Harvard University","keywords":"Translocon; Sec61; Endoplasmic reticulum; Cell biology; Transport protein; Chemistry; Biophysics; Biochemistry; Membrane protein; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009592873,0.0002098733,0.0002434113,0.00008357116,0.00008809215,0.0003007333,0.0001842518,0.0002346843,0.0010113],"category_scores_gemma":[0.0001284251,0.00009087966,0.000161906,0.00007690218,0.00019673,0.0002150624,0.0001684332,0.0003154324,0.0002012863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001575594,"about_ca_system_score_gemma":0.0000839829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002705772,"about_ca_topic_score_gemma":0.0003229549,"domain_scores_codex":[0.9999087,0.00001815489,0.00000950361,0.00001543402,0.00002201454,0.00002607064],"domain_scores_gemma":[0.9998727,0.0000342789,0.00003278723,0.00001735282,0.0000126617,0.00003026077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002032734,0.00001802809,0.00006161189,0.00001416325,0.000001878717,0.00001999051,0.000006390198,0.00002088626,0.9993514,0.00001156337,0.000007697692,0.0002830953],"study_design_scores_gemma":[0.00001307929,0.0003081278,0.001945567,0.000002225941,0.000005264379,0.00004271158,0.00001213763,0.0006347505,0.9967661,0.000009976108,0.0002579693,0.000002138669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987898,0.0003340644,0.000564027,0.00002972288,0.000007255079,0.000007025181,0.00005013186,0.00003449947,0.0001834328],"genre_scores_gemma":[0.9985475,0.0001357475,0.0006718282,0.00002723854,0.000003628246,0.000007605213,0.00005492249,0.000007279527,0.0005443412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010113,"threshold_uncertainty_score":0.00338316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800531961152624,"score_gpt":0.1960167917580826,"score_spread":0.1880114721465564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}