{"id":"W3160401327","doi":"10.1101/2021.05.12.443793","title":"Mycolactone enhances the Ca <sup>2+</sup> leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca <sup>2+</sup> permeable state","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Universität des Saarlandes; Weill Cornell Medical College; Deutsche Forschungsgemeinschaft; Wellcome Trust; Harvard University","keywords":"Translocon; Sec61; Endoplasmic reticulum; Cell biology; Transport protein; Chemistry; Biophysics; Biochemistry; Membrane protein; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001216499,0.001501772,0.001860082,0.0004175857,0.0007327069,0.000516179,0.001752699,0.00178886,0.002543774],"category_scores_gemma":[0.0002570323,0.001401967,0.0005764429,0.0008173825,0.0006122607,0.0004301759,0.0006832278,0.003954285,0.0005080861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004366001,"about_ca_system_score_gemma":0.001353649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004343902,"about_ca_topic_score_gemma":0.0001720456,"domain_scores_codex":[0.9924206,0.00135389,0.001607986,0.002370693,0.000304185,0.001942669],"domain_scores_gemma":[0.9959501,0.0004698005,0.0006433933,0.002395461,0.0003524031,0.0001888254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636869,0.0004741108,0.0001550836,0.0002267835,0.0009813089,0.000148986,0.002300357,0.003135768,0.9903558,0.00004592432,0.002002198,0.000009996174],"study_design_scores_gemma":[0.002766569,0.0001732099,0.001071346,0.001122702,0.0003386574,6.890136e-7,0.001189895,0.003269254,0.9673501,0.00001024562,0.02095747,0.001749843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749179,0.01560612,0.001506744,0.0006781683,0.00120259,0.001975171,0.003728477,0.000355329,0.00002953094],"genre_scores_gemma":[0.9940288,0.002978975,0.0007103187,0.0006837836,0.0001776873,0.0008642115,0.0000524729,0.0002642672,0.0002394846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02300568,"threshold_uncertainty_score":0.9997731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800531961152624,"score_gpt":0.1960167917580826,"score_spread":0.1880114721465564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}