{"id":"W3160455753","doi":"10.1038/s41467-021-22956-w","title":"Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Région Auvergne-Rhône-Alpes; Centre National de la Recherche Scientifique; Indo-French Centre for the Promotion of Advanced Research; Fondation Innovations en Infectiologie; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Alliance Française contre les Maladies Parasitaires; Université Grenoble Alpes","keywords":"Lipidome; Phosphatidic acid; Diacylglycerol kinase; Lipidomics; Lipid droplet; Apicoplast; Biology; Biogenesis; Lipotoxicity; Cell biology; Intracellular parasite; Intracellular; Biochemistry; Lipid metabolism; Lipogenesis; Phospholipid; Plastid; Membrane; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020378,0.0002734147,0.0002060638,0.000130518,0.0001867505,0.0003462043,0.0001008765,0.0002553509,0.001140363],"category_scores_gemma":[0.0001134595,0.0001004841,0.0001649735,0.0001326131,0.0002771085,0.0001644775,0.0002464113,0.0003248744,0.0004428635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003084989,"about_ca_system_score_gemma":0.0002377033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004309197,"about_ca_topic_score_gemma":0.0006613614,"domain_scores_codex":[0.9999185,0.00001271225,0.000005591427,0.0000230002,0.00002531381,0.00001498505],"domain_scores_gemma":[0.9999095,0.00001798304,0.00002804854,0.000009600617,0.000009046381,0.0000258413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009859844,0.00000511081,0.0003271454,0.00003652452,0.000002436519,0.00008795156,0.00000761605,0.00004644292,0.9982229,0.000156005,0.00005310903,0.0009562689],"study_design_scores_gemma":[0.00001831184,0.00008329726,0.0112619,0.00001529816,0.00001243354,0.0005490148,0.00004525995,0.001070548,0.9801741,0.000382651,0.006380873,0.000006337038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818147,0.002545192,0.009741058,0.0004598774,0.00007909998,0.00002881015,0.00176364,0.0003338438,0.003233765],"genre_scores_gemma":[0.9927462,0.0007610428,0.002800237,0.00009537781,0.000007673947,0.00001783402,0.001191458,0.00004832286,0.002331887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140363,"threshold_uncertainty_score":0.003814876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192609798891499,"score_gpt":0.3054497768914016,"score_spread":0.2835236789024866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}