{"id":"W3160455753","doi":"10.1038/s41467-021-22956-w","title":"Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Région Auvergne-Rhône-Alpes; Centre National de la Recherche Scientifique; Indo-French Centre for the Promotion of Advanced Research; Fondation Innovations en Infectiologie; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Alliance Française contre les Maladies Parasitaires; Université Grenoble Alpes","keywords":"Lipidome; Phosphatidic acid; Diacylglycerol kinase; Lipidomics; Lipid droplet; Apicoplast; Biology; Biogenesis; Lipotoxicity; Cell biology; Intracellular parasite; Intracellular; Biochemistry; Lipid metabolism; Lipogenesis; Phospholipid; Plastid; Membrane; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003034209,0.0002367464,0.0003998477,0.0001989657,0.0006607948,0.00005287622,0.0007979529,0.0006723825,0.0001840991],"category_scores_gemma":[0.0006817714,0.0002434296,0.00009981676,0.0006715308,0.000530983,0.0001954895,0.001416259,0.001585498,0.000134967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006694075,"about_ca_system_score_gemma":0.0001517675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001649501,"about_ca_topic_score_gemma":0.003783161,"domain_scores_codex":[0.9980781,0.0005814411,0.0003544897,0.0004466425,0.00008108195,0.0004582553],"domain_scores_gemma":[0.9972573,0.0008455216,0.000101847,0.001501593,0.0002589687,0.00003479365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007740022,0.0004837371,0.004914691,0.00007273167,0.0004154505,0.00001439798,0.004573598,0.000006522044,0.9770548,0.003865039,0.007277314,0.001244306],"study_design_scores_gemma":[0.001802348,0.00007676231,0.01328288,0.0001639205,0.0000833974,0.0001374634,0.002676236,0.00005841477,0.4301747,0.00009362715,0.5509552,0.0004950131],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7977993,0.1612564,0.00007346762,0.03482284,0.001426945,0.0005862991,0.0005391924,0.0001891085,0.003306402],"genre_scores_gemma":[0.9662331,0.0292052,0.001623092,0.0006382308,0.00009214897,0.00009234712,0.0006920501,0.00002898632,0.001394894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5468801,"threshold_uncertainty_score":0.992677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192609798891499,"score_gpt":0.3054497768914016,"score_spread":0.2835236789024866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}