{"id":"W3160457845","doi":"10.1016/j.bbamcr.2021.119059","title":"The role of GSK3 in metabolic pathway perturbations in cancer","year":2021,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"PI3K/AKT/mTOR pathway; AMPK; Autophagy; Wnt signaling pathway; GSK-3; Metabolic pathway; Protein kinase B; Biology; Cancer; Signal transduction; Cancer cell; Glycogen synthase; Cell biology; Glycogen; Cancer research; Kinase; Metabolism; Protein kinase A; Phosphorylation; Biochemistry; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003904734,0.001024584,0.001110542,0.002226676,0.000264377,0.001010417,0.0005896434,0.0009023065,0.002253416],"category_scores_gemma":[0.0003427624,0.0003252587,0.0004395166,0.001984674,0.0004614352,0.001098518,0.0007824397,0.001899113,0.002293293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006442478,"about_ca_system_score_gemma":0.0008384487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006731784,"about_ca_topic_score_gemma":0.001339398,"domain_scores_codex":[0.9998786,0.00001620194,0.000020764,0.00002487912,0.00004245194,0.00001707067],"domain_scores_gemma":[0.9998741,0.00004703956,0.00001986793,0.000004985885,0.00003664913,0.00001737113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001153631,0.00006029937,0.000174399,0.01256123,0.00009026527,0.0003552854,0.00006609435,0.0005395249,0.005237699,0.005377193,0.02345776,0.951965],"study_design_scores_gemma":[0.00002648369,0.0001066099,0.0008051574,0.001905349,0.0001074105,0.001284193,0.00004682664,0.0001228786,0.001781694,0.003072447,0.9907154,0.00002565262],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001557635,0.9985195,0.0001157076,0.0001503403,0.0001639097,0.000003062371,0.00001761271,0.000008485122,0.0008656856],"genre_scores_gemma":[0.0008139731,0.9983019,0.0001364467,0.000104813,0.0001034997,0.000005440693,0.00003445339,0.000001508785,0.0004979983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002253416,"threshold_uncertainty_score":0.007538438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04485397239288476,"score_gpt":0.3861486372269181,"score_spread":0.3412946648340334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}