{"id":"W3160462781","doi":"10.1111/febs.15963","title":"Oncohistones: a roadmap to stalled development","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; Chromatin; Histone; Carcinogenesis; Histone H3; Genetics; Computational biology; DNA methylation; Epigenesis; Genome; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004485047,0.0003071624,0.0007287154,0.0001284213,0.0001602103,0.0001067311,0.0002820189,0.0003212991,0.0001159791],"category_scores_gemma":[0.0001428024,0.0002617353,0.0003892085,0.0001443666,0.00001411893,0.000001674769,0.0001794143,0.0002976161,0.00007645776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206653,"about_ca_system_score_gemma":0.001378513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001192994,"about_ca_topic_score_gemma":0.00001204327,"domain_scores_codex":[0.998278,0.0001813509,0.0006452924,0.0003579188,0.0002514292,0.0002860199],"domain_scores_gemma":[0.9989079,0.00001336291,0.0003125373,0.0003063313,0.0001875245,0.000272319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004647532,0.00004204609,0.000003111599,0.0004276879,0.0002007108,0.00003603692,0.00005289889,0.000009687679,0.0003621788,0.000004428181,0.002536427,0.9963201],"study_design_scores_gemma":[0.0001300116,0.0001006054,0.000005354668,0.001776544,0.0001060147,0.000123358,0.00001329522,1.668274e-7,0.0005593624,0.000005839663,0.996855,0.0003244761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002426358,0.9944231,0.003534166,0.00001904817,0.0006085591,0.0002251171,0.000008086311,0.00000464686,0.0009346588],"genre_scores_gemma":[0.00001561531,0.988863,0.006349342,0.00005366041,0.0009214117,0.00003133715,0.0002465303,0.00005547136,0.003463621],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9959956,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440414142728069,"score_gpt":0.3725696889969806,"score_spread":0.3181655475696999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}