{"id":"W3160462781","doi":"10.1111/febs.15963","title":"Oncohistones: a roadmap to stalled development","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; Chromatin; Histone; Carcinogenesis; Histone H3; Genetics; Computational biology; DNA methylation; Epigenesis; Genome; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000745443,0.0007717178,0.001068037,0.001575707,0.0002867488,0.0009832929,0.0009509833,0.001610827,0.006006157],"category_scores_gemma":[0.0009780178,0.000276762,0.0004476686,0.0009426264,0.0006607415,0.001698952,0.0009873403,0.002666963,0.003354877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009154149,"about_ca_system_score_gemma":0.001124716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006432018,"about_ca_topic_score_gemma":0.001213453,"domain_scores_codex":[0.9998302,0.00003357646,0.00002495581,0.00003045139,0.00005260189,0.00002817935],"domain_scores_gemma":[0.9996177,0.0001945631,0.00003864129,0.00001391685,0.00007589619,0.00005932419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001683742,0.00005462152,0.0001736309,0.01066543,0.00006206168,0.0005545371,0.00005311658,0.0004305464,0.001388791,0.01222431,0.0661562,0.9080684],"study_design_scores_gemma":[0.00002033155,0.00005993313,0.0002531262,0.00118498,0.00003285944,0.001148508,0.00002569641,0.00004855241,0.0003340271,0.002892505,0.9939904,0.000009115128],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001398611,0.9970123,0.0001789601,0.0009029356,0.0005188835,0.000004126691,0.00002316554,0.00002295952,0.001196861],"genre_scores_gemma":[0.001267026,0.9958141,0.0002744571,0.0008127411,0.0004583744,0.000008941144,0.00006228751,0.000006335718,0.001295683],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006006157,"threshold_uncertainty_score":0.02009261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440414142728069,"score_gpt":0.3725696889969806,"score_spread":0.3181655475696999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}