{"id":"W3160508771","doi":"10.22203/ecm.v041a33","title":"Tungsten accumulates in the intervertebral disc and vertebrae stimulating disc degeneration and upregulating markers of inflammation and pain","year":2021,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; Dartmouth College; Office of Science; Canada Research Chairs; Brookhaven National Laboratory; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; U.S. Department of Energy","keywords":"Calcitonin gene-related peptide; Nerve growth factor; Fibrosis; Inflammation; Intervertebral disc; Sodium tungstate; Internal medicine; Medicine; Pathology; Chemistry; Endocrinology; Anatomy; Tungsten; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101582,0.0003452083,0.0003086448,0.0004473031,0.000160308,0.0002485574,0.0001400095,0.0004189766,0.001106377],"category_scores_gemma":[0.0001390731,0.000192423,0.0003724717,0.0001862496,0.000270267,0.0001797585,0.0002598627,0.0003506884,0.0001300431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810994,"about_ca_system_score_gemma":0.0001915087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005841603,"about_ca_topic_score_gemma":0.001550925,"domain_scores_codex":[0.9998571,0.00002149771,0.00001395711,0.00003127868,0.00004308368,0.00003311077],"domain_scores_gemma":[0.9998461,0.0000174465,0.00007064416,0.00001133559,0.00002933255,0.00002513558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002351843,0.00002754206,0.001193829,0.0001327918,0.00001329759,0.0001041142,0.00003635064,0.00002332072,0.9966001,0.00005251923,0.00001386354,0.001567106],"study_design_scores_gemma":[0.00004127929,0.002526432,0.07023647,0.00006030695,0.0001360493,0.0008516287,0.000321696,0.0004753835,0.9220513,0.0003317136,0.002950276,0.00001730316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898462,0.005204923,0.003466529,0.0001089163,0.00004099299,0.00003772578,0.0001608316,0.00004088032,0.001092983],"genre_scores_gemma":[0.9913427,0.00283622,0.002089419,0.00005499748,0.00001417366,0.0000388519,0.0001504099,0.000007380417,0.00346591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106377,"threshold_uncertainty_score":0.00370121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925364767744248,"score_gpt":0.2614645259338204,"score_spread":0.2422108782563779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}