{"id":"W3160653994","doi":"10.1101/2021.05.11.443286","title":"Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; McMaster University; Saskatoon Medical Imaging; University of Saskatchewan; University of Waterloo; Sunnybrook Health Science Centre; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; Sunnybrook Hospital; Hamilton Health Sciences; University of Toronto","funders":"Canadian Institutes of Health Research; Krembil Foundation; Royal Bank of Canada","keywords":"Vaccination; Immunology; Immune system; Virology; Medicine; Clinical trial; Hamster; Antibody; Neutralizing antibody; Adverse effect; Mesocricetus; Pandemic; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Pharmacology; Infectious disease (medical specialty); Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005662466,0.0005004506,0.0003602102,0.0002513732,0.0001951262,0.0002956091,0.0003072034,0.0004376783,0.001943435],"category_scores_gemma":[0.000193899,0.0001715393,0.0003153362,0.0001284398,0.0002764835,0.0002838511,0.0001705215,0.001066912,0.0004426567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003692662,"about_ca_system_score_gemma":0.0006665371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008827022,"about_ca_topic_score_gemma":0.001045198,"domain_scores_codex":[0.9998259,0.00003434332,0.000008723009,0.00003204858,0.00005038608,0.00004858506],"domain_scores_gemma":[0.9998738,0.000011709,0.00002833318,0.000009607847,0.00003561509,0.00004086391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001531685,0.002892643,0.0004728472,0.0002164105,0.0000362227,0.00007483456,0.00006035451,0.001302171,0.9819648,0.0002152094,0.0007139075,0.01051887],"study_design_scores_gemma":[0.001243271,0.1297689,0.003803736,0.00005437956,0.0001819828,0.0003489085,0.00008849338,0.003231711,0.8482372,0.0001522032,0.01287019,0.00001908906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870374,0.00167435,0.005445222,0.0003222066,0.000186167,0.001254817,0.001030202,0.0001272416,0.002922372],"genre_scores_gemma":[0.9863911,0.002067836,0.004352125,0.0001875849,0.00004778949,0.0006815651,0.00188403,0.00002645431,0.004361603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001943435,"threshold_uncertainty_score":0.006501436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09936700158098169,"score_gpt":0.378707907763018,"score_spread":0.2793409061820363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}