{"id":"W3160668788","doi":"10.1038/s41392-021-00569-5","title":"Targeting circular RNAs as a therapeutic approach: current strategies and challenges","year":2021,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":561,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital","funders":"Canadian Institutes of Health Research","keywords":"Circular RNA; Gene knockdown; Computational biology; Biology; RNA interference; Microvesicles; Function (biology); Exosome; Bioinformatics; microRNA; RNA; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000235864,0.0005670142,0.0008494873,0.0001108502,0.0001710881,0.0001647431,0.0001687527,0.0003753547,0.00009551996],"category_scores_gemma":[0.00001120174,0.0004935506,0.0004173646,0.0001388673,0.0001955271,0.00001814838,0.00003231318,0.0003359677,0.00000230518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001551423,"about_ca_system_score_gemma":0.0003186771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004426808,"about_ca_topic_score_gemma":5.332939e-7,"domain_scores_codex":[0.9976745,0.0004555244,0.0004011454,0.0009232612,0.000221754,0.0003237916],"domain_scores_gemma":[0.999253,0.00002117841,0.0001674997,0.0003180292,0.00008335686,0.0001569838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002500425,0.0001701281,0.00000123591,0.004083822,0.0007614483,0.000006629874,0.0001462228,0.000006274257,0.002950126,0.0007156838,0.00001667182,0.9911168],"study_design_scores_gemma":[0.0004819782,0.0001655664,0.000004922996,0.000692191,0.0003060303,0.0001757058,0.0007004122,0.000006565899,0.0003518449,0.0003064518,0.9962234,0.0005848518],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002311452,0.9969308,0.001715346,0.00003397586,0.0002561095,0.00062459,0.00003469272,0.00003984481,0.000133519],"genre_scores_gemma":[0.004493141,0.9938065,0.00009189415,0.0000378039,0.0005602947,0.0001508065,0.0007520013,0.00009133499,0.00001616837],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962068,"threshold_uncertainty_score":0.9997516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08003431253310524,"score_gpt":0.321686253947653,"score_spread":0.2416519414145478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}