{"id":"W3160703891","doi":"10.1016/j.trechm.2021.04.002","title":"Bioinspired dearomatization of DBCOD lignans","year":2021,"lang":"en","type":"article","venue":"Trends in Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Yield (engineering); Combinatorial chemistry; Oxidative phosphorylation; Biosynthesis; Redox; Selectivity; Stereochemistry; Organic chemistry; Biochemistry; Materials science; Gene; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618687,0.0003381008,0.0001611357,0.0001302301,0.0001062449,0.0001858575,0.0001790456,0.0001709795,0.001849617],"category_scores_gemma":[0.0001262547,0.00005844221,0.0002148564,0.0001407209,0.0001063985,0.0002265447,0.0002436507,0.0005825362,0.0004356482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019602,"about_ca_system_score_gemma":0.0002627494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005779904,"about_ca_topic_score_gemma":0.001744673,"domain_scores_codex":[0.9999309,0.000006319376,0.000002937337,0.00001221941,0.00001604461,0.00003154524],"domain_scores_gemma":[0.999952,0.000003900182,0.000009631618,0.000007992739,0.00001352201,0.00001306468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009270778,0.00007727261,0.0001861458,0.00007672291,0.00001427949,0.0000670743,0.00002668049,0.0002156799,0.9910267,0.0004189708,0.0001692313,0.007628506],"study_design_scores_gemma":[0.000004614849,0.0001225496,0.0003529723,0.000005088941,0.000006024072,0.00004232492,0.00001678838,0.0002265316,0.9969754,0.00003706295,0.002207698,0.000002799322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798728,0.001587779,0.009959249,0.000231729,0.0001392162,0.00007582433,0.0003793532,0.0001114876,0.007642508],"genre_scores_gemma":[0.9899978,0.001069725,0.002935172,0.00009521131,0.00001282689,0.00001804836,0.0004390755,0.00002602322,0.005406077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001849617,"threshold_uncertainty_score":0.006187618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246990208964429,"score_gpt":0.246312738056086,"score_spread":0.2338428359664417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}