{"id":"W3160703891","doi":"10.1016/j.trechm.2021.04.002","title":"Bioinspired dearomatization of DBCOD lignans","year":2021,"lang":"en","type":"article","venue":"Trends in Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Yield (engineering); Combinatorial chemistry; Oxidative phosphorylation; Biosynthesis; Redox; Selectivity; Stereochemistry; Organic chemistry; Biochemistry; Materials science; Gene; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007578084,0.0001094637,0.0001524336,0.00002424917,0.00001946725,0.000007709553,0.0001056017,0.0001656077,0.0001224437],"category_scores_gemma":[0.00004655691,0.0001107391,0.0000759678,0.0001858421,0.0000458818,0.000002799088,0.00005771276,0.00005348829,0.000001474862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001188984,"about_ca_system_score_gemma":0.00006012069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001082827,"about_ca_topic_score_gemma":0.00003853818,"domain_scores_codex":[0.9992799,0.00002583125,0.0001943254,0.0002573088,0.00009387069,0.0001487305],"domain_scores_gemma":[0.9995597,0.00001078751,0.00008077808,0.0002717449,0.00003907896,0.00003790367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001824626,0.0001315047,0.00621114,0.00003922498,0.0000192061,0.000009163939,0.0000179823,0.00001017239,0.9861358,0.00000457154,0.000307708,0.007095328],"study_design_scores_gemma":[0.0002716754,0.00001518713,0.007006467,0.00003484078,0.000009231966,0.00001989463,0.00004702781,0.00003410463,0.9908229,0.00001286961,0.001602478,0.000123316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877975,0.0003133204,0.00009073091,0.00008396554,0.00003054731,0.00001549684,0.0000685651,0.000008302404,0.01159156],"genre_scores_gemma":[0.9978362,0.00009122576,0.0005827427,0.00002344465,0.00006245256,0.000005304579,0.0003653665,0.00001069893,0.001022554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.010569,"threshold_uncertainty_score":0.451581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246990208964429,"score_gpt":0.246312738056086,"score_spread":0.2338428359664417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}