{"id":"W3160739477","doi":"10.1016/j.stemcr.2021.04.018","title":"Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; National Institute on Aging; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; British Heart Foundation","keywords":"Telomere; Shelterin; Biology; Induced pluripotent stem cell; Telomerase; Cell biology; Myocyte; Duchenne muscular dystrophy; Stem cell; Myogenesis; Cancer research; DNA damage; Embryonic stem cell; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484638,0.0001331289,0.0002080105,0.00003807611,0.00006544151,0.00001800251,0.00003056968,0.0001595335,0.0000254092],"category_scores_gemma":[0.00003100089,0.0001358636,0.00004731075,0.00009112846,0.00005143996,0.00000638298,0.00004977226,0.00009733822,0.000001364681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001157811,"about_ca_system_score_gemma":0.0001292977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008462409,"about_ca_topic_score_gemma":0.00005099703,"domain_scores_codex":[0.9989446,0.00008558502,0.0002571871,0.0004361204,0.00008246701,0.0001940155],"domain_scores_gemma":[0.9994645,0.0000208208,0.0001078507,0.0002724084,0.00006341634,0.0000709991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342808,0.00005427346,0.01442437,0.00005366912,0.0000369339,0.0006736604,0.00003024706,0.0001223633,0.9748549,0.000006640801,0.0001739188,0.009434695],"study_design_scores_gemma":[0.001271875,0.0001603552,0.08952847,0.00003896603,0.00006836293,0.0006432456,0.0009746599,0.00004997768,0.8948638,0.0001375648,0.01183494,0.0004277906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928246,0.003013706,0.00008694456,0.0000191486,0.0002232804,0.0001368734,0.000003312591,0.00001185941,0.003680332],"genre_scores_gemma":[0.9990993,0.0001662734,0.00003879398,0.00005290095,0.00007315815,0.00002539147,0.0001161283,0.00001481842,0.0004132597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07999115,"threshold_uncertainty_score":0.5540357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005751269367047078,"score_gpt":0.2154351699018775,"score_spread":0.2096839005348304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}