{"id":"W3160739477","doi":"10.1016/j.stemcr.2021.04.018","title":"Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; National Institute on Aging; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; British Heart Foundation","keywords":"Telomere; Shelterin; Biology; Induced pluripotent stem cell; Telomerase; Cell biology; Myocyte; Duchenne muscular dystrophy; Stem cell; Myogenesis; Cancer research; DNA damage; Embryonic stem cell; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304252,0.0001576057,0.0001403708,0.0001289585,0.0000841954,0.0001394292,0.00008036962,0.00020323,0.0007994884],"category_scores_gemma":[0.00009451334,0.00009481621,0.0001030292,0.00006827673,0.0001331727,0.00008641704,0.0001930616,0.000252702,0.0001222797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220093,"about_ca_system_score_gemma":0.00006239929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992686,"about_ca_topic_score_gemma":0.0004675702,"domain_scores_codex":[0.9999216,0.00001433116,0.000008473763,0.00001680738,0.00002193678,0.00001694792],"domain_scores_gemma":[0.9999249,0.00001506984,0.00002802325,0.000007730464,0.000004591252,0.00001960787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003593335,0.000006247282,0.0002752491,0.00001358117,0.000002394196,0.00008999128,0.000008105938,0.00002024565,0.9991498,0.00001887954,0.0000139654,0.0003656003],"study_design_scores_gemma":[0.00003331586,0.0005857712,0.07807926,0.00002162305,0.00002226807,0.001573298,0.0001038394,0.001097184,0.9168223,0.00012602,0.001527365,0.000007749934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977608,0.0009280354,0.0006552815,0.00005685383,0.00001089986,0.000005892828,0.00008318272,0.00001703329,0.0004819523],"genre_scores_gemma":[0.9982725,0.0005437719,0.0003205268,0.00004661981,0.000006589056,0.00001242824,0.00009551123,0.000003477378,0.0006985323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007994884,"threshold_uncertainty_score":0.00267452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005751269367047078,"score_gpt":0.2154351699018775,"score_spread":0.2096839005348304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}