{"id":"W3160781037","doi":"10.1186/s40478-021-01190-x","title":"Early onset senescence and cognitive impairment in a murine model of repeated mTBI","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Senescence; Neurodegeneration; Traumatic brain injury; DNA damage; Gliosis; Medicine; Neuroscience; Oxidative stress; Morris water navigation task; Pathology; Biology; Hippocampus; Disease; Internal medicine; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003469424,0.001196357,0.0004907991,0.001456057,0.0003258149,0.0004877388,0.0004927064,0.001147375,0.001308863],"category_scores_gemma":[0.0002396729,0.0004628038,0.0006359229,0.0003371953,0.0005670762,0.000504174,0.0004005429,0.001379267,0.000626911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757705,"about_ca_system_score_gemma":0.0003735418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006311959,"about_ca_topic_score_gemma":0.001115028,"domain_scores_codex":[0.9997234,0.0000373441,0.00003217605,0.00007977712,0.00007102945,0.00005631858],"domain_scores_gemma":[0.9995894,0.00001678046,0.0001778315,0.00005614122,0.00004994475,0.000109982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004424874,0.0003044614,0.0007048881,0.00008716164,0.00001876037,0.0002076349,0.0000751538,0.0001040291,0.9961885,0.000153119,0.00008010859,0.001633819],"study_design_scores_gemma":[0.0003121763,0.01351584,0.05260256,0.0002600534,0.0001955792,0.004094573,0.0002533422,0.002703304,0.9156322,0.0008234364,0.009547759,0.00005923351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879497,0.003768267,0.005387184,0.0002782796,0.00007663154,0.0001803738,0.0008668734,0.0002529305,0.00123969],"genre_scores_gemma":[0.9768356,0.00461881,0.007032753,0.0002972061,0.00004798008,0.0004849805,0.001637388,0.00007162373,0.008973654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456057,"threshold_uncertainty_score":0.004378557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03265953717430698,"score_gpt":0.2758574179514153,"score_spread":0.2431978807771084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}