{"id":"W3160805482","doi":"10.1101/2021.05.11.21256917","title":"Methotrexate Hampers Immunogenicity to BNT162b2 mRNA COVID-19 Vaccine in Immune-Mediated Inflammatory Disease","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Immunogenicity; Immune system; Immunology; Vaccination; Medicine; Methotrexate; Antibody; Immunization; Adjuvant; CD8","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002848784,0.0001989796,0.0003026518,0.0002113382,0.000154053,0.0002694226,0.00006619396,0.000184918,0.0008924752],"category_scores_gemma":[0.0006146714,0.00007785662,0.0001235896,0.0001272528,0.0001530697,0.0001471715,0.0001191291,0.0001966253,0.0002055048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656795,"about_ca_system_score_gemma":0.0001017476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256013,"about_ca_topic_score_gemma":0.0003644999,"domain_scores_codex":[0.9997852,0.00007491758,0.00002569596,0.00004363246,0.0000330355,0.00003743456],"domain_scores_gemma":[0.9996945,0.00007601285,0.0001299549,0.00002535701,0.00003153698,0.00004276853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005047255,0.0003911566,0.6891577,0.0001102702,0.00007464415,0.001267985,0.0002264333,0.0001765881,0.2815152,0.00007323853,0.0002621075,0.02169736],"study_design_scores_gemma":[0.0001140219,0.004713173,0.9674028,0.00002009007,0.00007888868,0.002638778,0.0001970605,0.0005519466,0.02314303,0.00003847999,0.001096443,0.00000518954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999405,0.0002592232,0.00006563245,0.0000160371,0.000002910222,0.000006370291,0.00002063712,0.000002505502,0.000221723],"genre_scores_gemma":[0.9996887,0.00006817414,0.00005828607,0.00001927991,0.000007252474,0.000004134518,0.00004480427,8.358208e-7,0.0001084596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008924752,"threshold_uncertainty_score":0.002985656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0425199001163924,"score_gpt":0.357712032012004,"score_spread":0.3151921318956116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}