{"id":"W3160819927","doi":"10.1016/j.jpeds.2021.05.009","title":"Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Children and Adolescents with Obesity: A Meta-Analysis","year":2021,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Jewish General Hospital","funders":"Public Health Agency","keywords":"Medicine; Internal medicine; Liraglutide; Body mass index; Glycated hemoglobin; Insulin resistance; Adverse effect; Glucagon-like peptide 1 receptor; Endocrinology; Exenatide; Obesity; Weight loss; Childhood obesity; Weight management; Gastroenterology; Diabetes mellitus; Type 2 diabetes; Overweight; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0154128,0.002834873,0.01630983,0.003677834,0.0004811672,0.002616206,0.001531754,0.001929409,0.002231176],"category_scores_gemma":[0.02413878,0.001401415,0.04712236,0.003865315,0.0007075793,0.001187403,0.001006635,0.001908476,0.0002208802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001543729,"about_ca_system_score_gemma":0.001353181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003659433,"about_ca_topic_score_gemma":0.005573375,"domain_scores_codex":[0.9901285,0.005248241,0.002319382,0.001209505,0.0008469012,0.000247531],"domain_scores_gemma":[0.9866457,0.008850743,0.002634973,0.0007550599,0.0008398544,0.0002735661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006901873,0.00002805082,0.005623253,0.02329353,0.9600442,0.00006949898,0.00002124951,0.0004769619,0.0001776583,0.00002780498,0.0001284156,0.003207582],"study_design_scores_gemma":[0.001615781,0.0004109312,0.004691149,0.001378773,0.9911206,0.00007176924,0.00001719109,0.0001961717,0.0000834144,0.00006357396,0.0003394411,0.0000111727],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05740266,0.9381534,0.001806424,0.0003151752,0.0004173499,0.0004657122,0.0009076272,0.00007761255,0.0004540409],"genre_scores_gemma":[0.7450236,0.2482333,0.002828794,0.00100873,0.0004559232,0.0009322538,0.001082844,0.0000555691,0.0003790203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01630983,"threshold_uncertainty_score":0.08151168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322492355918484,"score_gpt":0.2442996693971971,"score_spread":0.2310747458380122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}