{"id":"W3160819927","doi":"10.1016/j.jpeds.2021.05.009","title":"Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Children and Adolescents with Obesity: A Meta-Analysis","year":2021,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Jewish General Hospital","funders":"Public Health Agency","keywords":"Medicine; Internal medicine; Liraglutide; Body mass index; Glycated hemoglobin; Insulin resistance; Adverse effect; Glucagon-like peptide 1 receptor; Endocrinology; Exenatide; Obesity; Weight loss; Childhood obesity; Weight management; Gastroenterology; Diabetes mellitus; Type 2 diabetes; Overweight; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005947669,0.000125108,0.0007262864,0.000243502,0.00003463249,0.00001589394,0.00007112701,0.00003347831,0.00002509692],"category_scores_gemma":[0.00005673122,0.00006873903,0.0002028264,0.0006431904,0.00005117039,0.00006181693,0.0000711542,0.0001557239,9.457712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003165558,"about_ca_system_score_gemma":0.00006576983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002294621,"about_ca_topic_score_gemma":0.00002696422,"domain_scores_codex":[0.9989335,0.0001065476,0.0003818927,0.0001109137,0.0003337156,0.0001334608],"domain_scores_gemma":[0.999155,0.00008412834,0.000337015,0.0001872763,0.0001404028,0.00009616596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006262037,0.000669267,0.9831924,0.000149215,0.01344539,0.0000419021,0.0004427612,0.00008596282,0.00004251415,0.00001285928,0.0002999799,0.0009915913],"study_design_scores_gemma":[0.0029578,0.0003246477,0.7999448,0.00001977629,0.1963418,0.00003960651,0.0001170735,0.000004320264,0.00009599808,0.000009192868,0.00007663905,0.00006837497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899209,0.009165348,0.00008391289,0.0005571424,0.00002375621,0.000177909,0.00000782531,0.000002857104,0.00006038032],"genre_scores_gemma":[0.9919523,0.006886015,0.0006478066,0.0001222124,0.00007143754,5.135025e-7,0.000007518592,0.000009317837,0.0003028865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1832476,"threshold_uncertainty_score":0.2803096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322492355918484,"score_gpt":0.2442996693971971,"score_spread":0.2310747458380122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}