{"id":"W3160827273","doi":"10.1002/alz.12330","title":"TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Innovative Medicines Initiative; National Institute on Aging; Deutsche Forschungsgemeinschaft; Medical Research Council; Cure Alzheimer's Fund; Steno Diabetes Center Copenhagen; European Federation of Pharmaceutical Industries and Associations; European Commission","keywords":"Genome-wide association study; Neurogranin; Biomarker; Biomarker discovery; Disease; Genetic association; Cerebrospinal fluid; Alzheimer's disease; Biology; Neuroscience; Computational biology; Medicine; Genetics; Proteomics; Genotype; Pathology; Single-nucleotide polymorphism; Gene; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037145,0.0007069457,0.0003229946,0.0007608645,0.0002816372,0.0005023722,0.0002846813,0.0005967993,0.002850864],"category_scores_gemma":[0.001776968,0.0001662254,0.0003173569,0.0007676124,0.000280627,0.0001886267,0.0003031754,0.0004055096,0.0002299382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897122,"about_ca_system_score_gemma":0.0001621551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520351,"about_ca_topic_score_gemma":0.00138155,"domain_scores_codex":[0.9996837,0.00006588395,0.00004993669,0.0001136375,0.000054588,0.00003230514],"domain_scores_gemma":[0.9991944,0.0002120532,0.0004113109,0.00005728999,0.00004839378,0.00007654683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003273654,0.0001498547,0.8738833,0.0001191994,0.000610346,0.001272219,0.0002179097,0.0005553698,0.1064275,0.0002652632,0.0005556297,0.01266958],"study_design_scores_gemma":[0.00004769156,0.0001309117,0.98506,0.00002269974,0.00015448,0.0020969,0.00006047978,0.0009902333,0.01056407,0.0003200476,0.0005411078,0.00001124291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978979,0.000374421,0.0006822066,0.00007500349,0.00001125468,0.000005372952,0.0006241198,0.00002133139,0.0003084865],"genre_scores_gemma":[0.9986197,0.00006047992,0.0007776645,0.00002361022,0.000009226402,0.000006780348,0.0003103012,0.000006863938,0.0001853068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002850864,"threshold_uncertainty_score":0.009537101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05004537464206883,"score_gpt":0.3293635552067077,"score_spread":0.2793181805646389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}