{"id":"W3160847691","doi":"10.1016/j.xpro.2021.100534","title":"Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors","year":2021,"lang":"en","type":"article","venue":"STAR Protocols","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Fonds De La Recherche Scientifique - FNRS; Fonds National de la Recherche Luxembourg; International Council for Canadian Studies; European Commission; FP7 Coherent Development of Research Policies","keywords":"Organoid; Glioma; Protocol (science); Medicine; Brain tumor; Oncology; Cancer research; Computer science; Pathology; Biology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004331919,0.0001932557,0.0003837822,0.00007803943,0.00007422251,0.0000279536,0.00003981635,0.00008101163,0.0002089663],"category_scores_gemma":[0.0001325144,0.0001555999,0.00009700366,0.0002152778,0.00005022777,0.00007267012,0.00006228083,0.00006139032,0.000002989389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005199478,"about_ca_system_score_gemma":0.000172639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000498624,"about_ca_topic_score_gemma":0.00002023058,"domain_scores_codex":[0.9986373,0.00005335346,0.0004702282,0.0003557099,0.0002647938,0.0002186492],"domain_scores_gemma":[0.9988869,0.00006899657,0.0002279154,0.00033936,0.0003514803,0.0001253809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001427279,0.002838933,0.08641269,0.001197333,0.0002602887,0.0002911041,0.001745113,0.000002022942,0.845997,0.0002313498,0.0008864793,0.05871037],"study_design_scores_gemma":[0.007980348,0.002605363,0.0417523,0.000746013,0.00004394429,0.00001931656,0.0002610529,0.00002289263,0.930665,0.0004155739,0.0153409,0.0001472547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5225397,0.00000544011,0.00003000784,0.0001436751,0.00001051138,0.4771553,0.00005380586,0.00002120322,0.00004035928],"genre_scores_gemma":[0.2061122,1.888794e-7,0.006322283,0.0001044495,0.00003255882,0.7873312,0.00006873018,0.00002373537,0.000004695032],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.3164275,"threshold_uncertainty_score":0.6345179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234963803478091,"score_gpt":0.3239993693163561,"score_spread":0.2916497312815752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}