{"id":"W3160870314","doi":"10.1186/s13195-021-00836-1","title":"Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Positron emission tomography; Neuroimaging; Nuclear medicine; Neurology; Dementia; Binding potential; White matter; Pipeline (software); Psychology; Medicine; Medical physics; Computer science; Neuroscience; Pathology; Magnetic resonance imaging; Disease; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004767695,0.0002140382,0.0005131421,0.0005882013,0.0001460296,0.00009193584,0.000258882,0.00004820757,0.0006439996],"category_scores_gemma":[0.0001688538,0.0001866192,0.0001732184,0.001555579,0.0002627052,0.0002521563,0.0002358661,0.0007877111,0.00005306816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006365896,"about_ca_system_score_gemma":0.000370058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006288973,"about_ca_topic_score_gemma":0.00006955858,"domain_scores_codex":[0.9938381,0.002126958,0.000520963,0.0007122781,0.00202766,0.0007740038],"domain_scores_gemma":[0.9974911,0.0002975164,0.00007177892,0.000699763,0.001195095,0.0002447098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001382922,0.01131355,0.8622552,0.00003916562,0.001251175,0.0008484226,0.001251835,0.000002401813,0.09845743,0.00005063726,0.0002564796,0.02289085],"study_design_scores_gemma":[0.007688825,0.001863807,0.8408231,0.00007002417,0.00009099006,0.0001104057,0.003474748,0.0001931652,0.1450377,0.00007227301,0.0003984736,0.0001765151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988187,0.003176238,0.00007567734,0.0004100622,0.0000532673,0.002636696,0.00001640309,0.00002830056,0.005416358],"genre_scores_gemma":[0.9968655,0.001476184,0.0005519999,0.00007918598,0.00009166648,0.000264831,0.000137029,0.00004119344,0.0004924346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0465803,"threshold_uncertainty_score":0.7610111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085053168860566,"score_gpt":0.4166184408711215,"score_spread":0.3081131239850649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}