{"id":"W3160930592","doi":"10.1016/j.cellsig.2021.110047","title":"Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses","year":2021,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Wnt signaling pathway; Cell biology; Biology; Unfolded protein response; Endoplasmic reticulum; Thapsigargin; Secretion; Gene silencing; Endocrinology; Internal medicine; Signal transduction; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461948,0.0002913084,0.0003111137,0.0001903659,0.0002230469,0.0004305702,0.0002456778,0.0003538445,0.001737676],"category_scores_gemma":[0.0002343455,0.0001730332,0.0002789361,0.0001939822,0.0003958688,0.0003140347,0.0002850142,0.000401881,0.0002516689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797678,"about_ca_system_score_gemma":0.0001979006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001899148,"about_ca_topic_score_gemma":0.002024715,"domain_scores_codex":[0.9998317,0.0000252782,0.00001084139,0.00003812293,0.00003444343,0.00005965156],"domain_scores_gemma":[0.9998614,0.00002213765,0.00003889631,0.00001653196,0.00001545787,0.00004555418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008474633,0.00002152768,0.0002698149,0.00003109499,0.000007671694,0.00005823493,0.00002337976,0.00004890115,0.9980709,0.00008724551,0.00003377117,0.0005000904],"study_design_scores_gemma":[0.00004471994,0.0001933336,0.02825162,0.0000084863,0.00002804666,0.0003500609,0.0002377418,0.001344449,0.9664503,0.0001075604,0.002971464,0.0000123139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973685,0.0006817998,0.0007155405,0.00010268,0.00001740457,0.000008186492,0.0002914147,0.00003996542,0.0007745594],"genre_scores_gemma":[0.9947318,0.0004877852,0.0005008526,0.00006737851,0.000006029541,0.00001821891,0.0006827659,0.00002350384,0.003481681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899148,"threshold_uncertainty_score":0.005813122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156937059893885,"score_gpt":0.2281140131075231,"score_spread":0.2165446425085843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}