{"id":"W3160938888","doi":"10.3390/ijms22105215","title":"Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary","funders":"Ministry of Higher Education and Scientific Research; University of Calgary","keywords":"Cell biology; Embryonic stem cell; Induced pluripotent stem cell; Stem cell; Notch signaling pathway; Cellular differentiation; Biology; Mesenchymal stem cell; Bone healing; Signal transduction; Anatomy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001910706,0.0003429853,0.0002613836,0.0002603505,0.00007408817,0.0002810833,0.0001646256,0.0001705845,0.001200116],"category_scores_gemma":[0.00012627,0.0001084569,0.0002653666,0.0001976822,0.0001487766,0.0001652514,0.000169795,0.0006233809,0.0002577866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339068,"about_ca_system_score_gemma":0.0002076905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002961434,"about_ca_topic_score_gemma":0.000434823,"domain_scores_codex":[0.9998366,0.00001498274,0.00003207042,0.00002686813,0.00006608634,0.00002346543],"domain_scores_gemma":[0.9999347,0.00001781805,0.00001661932,0.000008867546,0.00001083759,0.00001121741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004913929,0.00002022852,0.00007952761,0.00004409723,0.000005397475,0.00003699746,0.00001130029,0.0001173249,0.9972394,0.0001657684,0.00003691654,0.002193941],"study_design_scores_gemma":[0.00001102627,0.00007162297,0.0005679972,0.000004176271,0.00001504435,0.00006090818,0.000005112021,0.0005436067,0.9965988,0.00003183176,0.002088142,0.000001795589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765078,0.004130017,0.01120477,0.0002492254,0.0001162612,0.0001201172,0.001283135,0.0001618091,0.006226899],"genre_scores_gemma":[0.9867448,0.00334325,0.004446207,0.0001433085,0.00001737587,0.0000883241,0.001191461,0.00002650509,0.003998767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200116,"threshold_uncertainty_score":0.00401479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125111626445701,"score_gpt":0.2697049503824315,"score_spread":0.2571937877378614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}