{"id":"W3161017411","doi":"10.1097/qad.0000000000002936","title":"Virologic efficacy of tenofovir, lamivudine and dolutegravir as second-line antiretroviral therapy in adults failing a tenofovir-based first-line regimen","year":2021,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Wellcome Trust; McMaster University","keywords":"Dolutegravir; Lamivudine; Efavirenz; Emtricitabine; Medicine; Regimen; Viral load; Reverse-transcriptase inhibitor; Virology; Integrase inhibitor; Internal medicine; Abacavir; Gastroenterology; Virus; Antiretroviral therapy; Hepatitis B virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001081535,0.0002820024,0.0005390283,0.0001403092,0.0001651194,0.0004750431,0.0001836513,0.0004363635,0.001295714],"category_scores_gemma":[0.002030018,0.0001713004,0.0003431269,0.0001297392,0.0001832282,0.0003326763,0.0001640665,0.0005123358,0.0001271194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781798,"about_ca_system_score_gemma":0.0003629464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008785086,"about_ca_topic_score_gemma":0.001170143,"domain_scores_codex":[0.9996687,0.0001285817,0.0000314809,0.00006097415,0.00005536459,0.00005481787],"domain_scores_gemma":[0.9992392,0.0002428743,0.000213492,0.00003345295,0.00005929652,0.0002116517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2462211,0.0103902,0.5330937,0.001086471,0.0006909242,0.000549649,0.00158192,0.001142095,0.03449149,0.0002416306,0.0008678181,0.1696431],"study_design_scores_gemma":[0.02336403,0.2556115,0.7059034,0.0001950558,0.0005453947,0.001585518,0.0007049695,0.003682635,0.006614632,0.0001276622,0.001622211,0.00004288524],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990839,0.0006269203,0.0000211565,0.00002243322,0.000005470474,0.00002825531,0.00003431843,0.000002537198,0.0001749206],"genre_scores_gemma":[0.9996938,0.00008728642,0.00005655227,0.00002364353,0.000005780606,0.00001598216,0.00003572896,5.029805e-7,0.00008082449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295714,"threshold_uncertainty_score":0.005719781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582246092309223,"score_gpt":0.2659675206863135,"score_spread":0.2501450597632212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}