{"id":"W3161102292","doi":"10.1016/j.psyneuen.2021.105273","title":"Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams","year":2021,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Fluoxetine; Endocrinology; Internal medicine; Kynurenine; Antidepressant; Metabolite; Postpartum depression; Pharmacology; Kynurenine pathway; Chemistry; Serotonin; Medicine; Biology; Hippocampus; Tryptophan; Pregnancy; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689705,0.0002631864,0.0003531388,0.0003842608,0.0004256246,0.0005217924,0.0003393028,0.0004207105,0.002604513],"category_scores_gemma":[0.000730661,0.0004039133,0.0002063103,0.0001398052,0.0005316621,0.0005153966,0.0004021084,0.001282803,0.0004012962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101399,"about_ca_system_score_gemma":0.001025019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00577585,"about_ca_topic_score_gemma":0.01142533,"domain_scores_codex":[0.9997805,0.00003413332,0.000009682493,0.00006394884,0.00004243894,0.00006938801],"domain_scores_gemma":[0.9994749,0.00008058402,0.0001137825,0.00007297969,0.00006613285,0.0001915904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006287486,0.0003667028,0.01128353,0.0000980391,0.00003152359,0.0005790085,0.001037447,0.0001013322,0.9650592,0.0005622511,0.0006478009,0.01394566],"study_design_scores_gemma":[0.0003151245,0.004123691,0.3870317,0.0001212975,0.0002832894,0.001052187,0.004820676,0.002959967,0.5884874,0.002125934,0.008511714,0.0001670037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963803,0.0006448995,0.00091125,0.0004862788,0.00007963739,0.0000112218,0.0004490915,0.00005823085,0.0009791647],"genre_scores_gemma":[0.9915423,0.0007094769,0.0009732782,0.0002711606,0.00002257551,0.0000709704,0.0002897671,0.00005338394,0.006066976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00577585,"threshold_uncertainty_score":0.01148444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095555933166806,"score_gpt":0.3044270100033729,"score_spread":0.2834714506717049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}