{"id":"W3161102292","doi":"10.1016/j.psyneuen.2021.105273","title":"Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams","year":2021,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Fluoxetine; Endocrinology; Internal medicine; Kynurenine; Antidepressant; Metabolite; Postpartum depression; Pharmacology; Kynurenine pathway; Chemistry; Serotonin; Medicine; Biology; Hippocampus; Tryptophan; Pregnancy; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005728344,0.0002071032,0.0003678011,0.00008822381,0.00008924842,0.00001933382,0.0001077611,0.00005065202,0.000237108],"category_scores_gemma":[0.00007674391,0.0001557735,0.00005056114,0.0001979937,0.0001454647,0.00004954517,0.0001146036,0.0004799149,0.00007649601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002244367,"about_ca_system_score_gemma":0.00005495461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003632471,"about_ca_topic_score_gemma":0.00008794809,"domain_scores_codex":[0.9981555,0.0001975315,0.0004389441,0.0004648287,0.0001648378,0.0005783518],"domain_scores_gemma":[0.9990926,0.0001328839,0.00008481409,0.0004793717,0.00003671856,0.0001735812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008658706,0.003345757,0.8431074,0.005535862,0.0002350284,0.03631942,0.002838796,0.000005936593,0.0492895,0.01592471,0.001846504,0.03289239],"study_design_scores_gemma":[0.004349222,0.0008421037,0.9383928,0.0007561398,0.00003217694,0.00921277,0.00008764389,0.00002717191,0.02752139,0.000876648,0.01768966,0.0002123273],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493252,0.004425006,0.00001107924,0.04273189,0.001261629,0.0003808626,0.0000117885,0.00005728237,0.001795236],"genre_scores_gemma":[0.990654,0.001868358,0.000105112,0.005557667,0.0001479135,0.00006654878,0.00002213094,0.00002780019,0.001550466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09528536,"threshold_uncertainty_score":0.6352258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095555933166806,"score_gpt":0.3044270100033729,"score_spread":0.2834714506717049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}