{"id":"W3161110260","doi":"10.1002/9781119745532.ch9","title":"Clinical Trials in ALS – Current Challenges and Strategies for Future Directions","year":2021,"lang":"de","type":"other","venue":"","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Clinical trial; Riluzole; Disease; Medicine; Edaravone; Intensive care medicine; Drug development; Clinical study design; Drug; Amyotrophic lateral sclerosis; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3007064,0.002410177,0.00703775,0.005590296,0.003874051,0.02096923,0.008595684,0.02498014,0.03278274],"category_scores_gemma":[0.2336295,0.001689304,0.003768137,0.005014415,0.02452724,0.04782901,0.01294273,0.03539962,0.01092133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01062467,"about_ca_system_score_gemma":0.03969381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004334705,"about_ca_topic_score_gemma":0.006098946,"domain_scores_codex":[0.8993042,0.06832758,0.009836053,0.005012427,0.01458744,0.002932227],"domain_scores_gemma":[0.4982598,0.3953059,0.01165327,0.01651153,0.04836337,0.02990622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008493276,0.0005818906,0.0008243624,0.007548503,0.0002329465,0.0003523823,0.0006626168,0.001194266,0.0002849718,0.1745427,0.3348175,0.4781086],"study_design_scores_gemma":[0.0005389943,0.0005101796,0.00066895,0.02471258,0.0001597262,0.0003791293,0.001273023,0.001261967,0.0001143812,0.2586691,0.7115516,0.0001603754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0002439114,0.3528211,0.006434184,0.6215551,0.0128483,0.000184284,0.0001799498,0.0002594533,0.005473705],"genre_scores_gemma":[0.01252603,0.5636796,0.05217788,0.3023622,0.06038899,0.002218639,0.000677541,0.0003967136,0.005572349],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.3007064,"threshold_uncertainty_score":0.8623536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.355484165937258,"score_gpt":0.516653452196361,"score_spread":0.1611692862591031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}